Related Experiment Video

Updated: May 1, 2026

Human Mesenchymal Stem Cell Processing for Clinical Applications Using a Closed Semi-Automated Workflow
09:03

Human Mesenchymal Stem Cell Processing for Clinical Applications Using a Closed Semi-Automated Workflow

Published on: March 17, 2023

4.1K

Manufacturing challenges in regenerative medicine

Ivan Martin1, Paul J Simmons, David F Williams

  • 1Department of Biomedicine, University of Basel, 4031 Basel, Switzerland.

Science Translational Medicine
|April 18, 2014
PubMed

Abstract:

Along with scientific and regulatory issues, the translation of cell and tissue therapies in the routine clinical practice needs to address standardization and cost-effectiveness through the definition of suitable manufacturing paradigms.

More Related Videos

Automated Counterflow Centrifugal System for Small-Scale Cell Processing
04:49

Automated Counterflow Centrifugal System for Small-Scale Cell Processing

Published on: December 12, 2019

8.6K
Author Spotlight: Advancing Cell Therapy Manufacturing with Dissolvable Microcarriers
09:44

Author Spotlight: Advancing Cell Therapy Manufacturing with Dissolvable Microcarriers

Published on: July 7, 2023

5.0K

Related Experiment Videos

Last Updated: May 1, 2026

Human Mesenchymal Stem Cell Processing for Clinical Applications Using a Closed Semi-Automated Workflow
09:03

Human Mesenchymal Stem Cell Processing for Clinical Applications Using a Closed Semi-Automated Workflow

Published on: March 17, 2023

4.1K
Automated Counterflow Centrifugal System for Small-Scale Cell Processing
04:49

Automated Counterflow Centrifugal System for Small-Scale Cell Processing

Published on: December 12, 2019

8.6K
Author Spotlight: Advancing Cell Therapy Manufacturing with Dissolvable Microcarriers
09:44

Author Spotlight: Advancing Cell Therapy Manufacturing with Dissolvable Microcarriers

Published on: July 7, 2023

5.0K

Related Concept Videos

Upstream Processing01:27

Upstream Processing

97
Upstream processing represents a critical phase in biomanufacturing, wherein biological systems such as microorganisms, mammalian cells, or insect cells are cultivated to produce therapeutic proteins, vaccines, enzymes, or other biologically derived products. This phase encompasses all steps from the selection and genetic manipulation of the production organism to the cultivation of cells in bioreactors under tightly controlled environmental conditions.Host Selection and Genetic OptimizationThe...
97

Articles linked to this work by shared authors, journal, and citation graph.

A 3D engineered multiple myeloma niche for evaluating CAR T cell therapy.

Frontiers in bioengineering and biotechnology·2026

Vascularization of Human iPSC-Derived Kidney Organoids Using Perfusion Culture, Pre-Vascularized Collagen Scaffolds, and Decellularized Extracellular Matrix.

Advanced healthcare materials·2026

Intraocular inflammation and presumed retinal vasculitis following initial pegcetacoplan intravitreal injection.

Digital journal of ophthalmology : DJO·2026

A Fully Human Engineered Bone Niche With Endogenous Osteoclastogenesis Reveals Osteoclast-Dependent Osteomimicry in Prostate Cancer Cells.

Advanced healthcare materials·2026

Role of external forces in the mechanobiology of stem and differentiated chondrogenic cells embedded in a tissue-engineered construct for cartilage repair.

Journal of biomedical science·2026

Migration and Chondrogenesis of Cells from Minced Nasal Cartilage in Type I Collagen Hydrogel: A Workflow for One-Step Engineering of Injectable Grafts.

Gels (Basel, Switzerland)·2026

Human microglia clear intraneuronal α-synuclein aggregates by GPNMB-mediated trogocytosis.

Science translational medicine·2026

Aberrant erythrocyte rigidity in JAK2V617F myeloproliferative neoplasms underlies concurrent thrombosis and hemorrhage.

Science translational medicine·2026

Turning the tables: Repurposing neuroplasticity to defeat cancer.

Science translational medicine·2026

Transient receptor potential channel activation targets multiple stages of the schistosome parasite.

Science translational medicine·2026

Use of split intein and myotropic AAV vectors enables effective preclinical gene therapy for dysferlinopathy.

Science translational medicine·2026

Immunoregulatory artificial lymph nodes restore antigen-specific tolerance in advanced multiple sclerosis.

Science translational medicine·2026

Methotrexate in Still's Disease: An Updated Perspective on Efficacy and Safety.

Advances in therapy·2026

Effects of Spermidine Supplementation on Vascular Brain Health in Older Individuals with Subjective Cognitive Decline - An Exploratory MRI Analysis.

Aging and disease·2026

Comparison of treatment and outcome between Myelomeningocele and Myeloschisis after open fetal repair - experience after first 200 cases.

Fetal diagnosis and therapy·2026

Heparin Can Augment Extracellular Vesicle Yield by Inhibiting Reuptake in Donor Cells During Cell Propagation.

Journal of extracellular vesicles·2026

Surgery and/or biologics in chronic rhinosinusitis with nasal polyps: EUFOREA/EPOS consensus paper.

Rhinology·2026

Real-world epidemiology and management of patients with rheumatoid arthritis treated with methotrexate in France: a decade after methotrexate first recommendations.

EULAR rheumatology open·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
Jove
Visualize
Contact Us