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Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

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Updated: May 1, 2026

Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model

Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model

Published on: January 13, 2023

[Systemic therapy and hyperthermia for locally advanced soft tissue sarcoma].

L H Lindner¹, M Angele, H R Dürr

¹Medizinische Klinik III, Klinikum der Universität München - Campus Grosshadern, Marchioninistr. 15, 81377, München, Deutschland, lars.lindner@med.uni-muenchen.de.

Der Chirurg; Zeitschrift Fur Alle Gebiete Der Operativen Medizen

|April 18, 2014

Summary

Adding hyperthermia to chemotherapy for high-risk soft tissue sarcoma improves outcomes. This multimodal approach enhances tumor response and survival, offering a valuable treatment option.

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Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model

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Author Spotlight: Computing the Effects of a Local Radiofrequency Hyperthermia Intervention on Tumor Biomechanics

Author Spotlight: Computing the Effects of a Local Radiofrequency Hyperthermia Intervention on Tumor Biomechanics

Published on: December 1, 2023

Area of Science:

Oncology
Medical Physics

Context:

High-risk soft tissue sarcomas (FNCLCC grades 2-3, >5 cm, deep-seated) have poor prognoses despite surgery.
Multimodal therapy is crucial for managing these challenging tumors.

Purpose:

To evaluate the efficacy of hyperthermia as an adjunct to neoadjuvant chemotherapy in high-risk soft tissue sarcoma.
To assess the impact of hyperthermia on local recurrence and distant metastases.

Summary:

Hyperthermia, involving localized heating (40-43°C for 60 min) via microwave radiation, is a complementary therapy.
A randomized phase III study showed hyperthermia with neoadjuvant chemotherapy improved tumor response and reduced early progression.
Adding hyperthermia to multimodal regimens (surgery, radiation, chemotherapy) significantly improved local progression-free and disease-free survival.

Impact:

Hyperthermia, combined with chemotherapy, should be considered a standard treatment for locally advanced high-risk soft tissue sarcoma.
The generally good tolerability of hyperthermia supports its integration into standard care.
Improved survival outcomes for patients with high-risk soft tissue sarcoma.