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Growth in congenital rubella syndrome and correlation with clinical manifestations

S Chiriboga-Klein1, S E Oberfield, A M Casullo

  • 1Department of Pediatrics, St. Luke's-Roosevelt Hospital Center, New York, NY 10025.

The Journal of Pediatrics
|August 1, 1989
PubMed

Insights

Congenital rubella syndrome impacts growth, with cognitive deficits correlating to growth failure. This study observed three distinct growth patterns in affected children.

Area of Science:

  • Pediatrics
  • Virology
  • Genetics

Background:

  • Congenital rubella syndrome (CRS) results from maternal rubella infection during pregnancy.
  • CRS can lead to a spectrum of developmental and physical abnormalities.
  • Longitudinal growth data in CRS patients is crucial for understanding long-term outcomes.

Purpose of the Study:

  • To analyze growth patterns and final stature in patients with CRS.
  • To investigate the relationship between growth failure and cognitive deficits in CRS.
  • To explore the mechanisms by which the rubella virus affects somatic growth.

Main Methods:

  • Retrospective review of medical records for 105 patients with CRS.
  • Longitudinal follow-up data collection on growth parameters and final height.
  • Statistical analysis to correlate cognitive deficits with growth failure.

Main Results:

  • Three distinct growth patterns were identified: normal growth, persistent below-5th percentile growth, and early growth cessation.
  • Significant cognitive deficits were not observed in patients with normal growth, except in one case of profound mental retardation.
  • A strong correlation (p < 0.001) was found between the severity of cognitive deficits and the degree of growth failure.

Conclusions:

  • The rubella virus impacts somatic growth through mechanisms acting both in utero and postnatally.
  • Growth failure in CRS is closely linked to the severity of cognitive impairment.
  • Understanding these growth patterns is vital for managing and predicting outcomes in CRS patients.

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