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Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

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New insights into p53 functions through its target microRNAs

Jun-Ming Liao1, Bo Cao1, Xiang Zhou1

  • 1Department of Biochemistry & Molecular Biology and Tulane Cancer Center, Tulane University School of Medicine, New Orleans, LA 70112, USA.

Journal of Molecular Cell Biology
|April 18, 2014
PubMed

Insights

The p53 pathway, crucial in cancer prevention, involves microRNAs (miRNAs) that regulate its activity. This review explores p53 miRNA targets, their roles in stress responses, and broader disease implications beyond cancer.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • The tumor suppressor p53 pathway is critical for preventing cancer development and progression.
  • Alterations in the p53 pathway are frequently observed across various human cancers.
  • MicroRNAs (miRNAs) have emerged as key downstream regulators of the p53 pathway.

Purpose of the Study:

  • To review identified p53 microRNA targets.
  • To discuss the regulatory roles of these miRNAs in p53 activity.
  • To explore the involvement of p53-miRNA interactions in broader human diseases.

Main Methods:

  • Literature review of identified p53 miRNA targets.
  • Analysis of studies on miRNA regulation of p53.
  • Synthesis of information on p53-miRNA crosstalk in disease.

Main Results:

  • Numerous p53 miRNA targets have been identified.
  • These miRNAs exhibit complex regulatory functions on p53 activity.
  • P53-miRNA interactions fine-tune cellular stress responses.

Conclusions:

  • MicroRNAs are integral to the p53 pathway's function.
  • P53-miRNA networks mediate crosstalk with other signaling pathways.
  • Understanding these interactions expands the role of p53 in human diseases, including cancer.
Keywords:
cancermiRNAp53tumorigenesis

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