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Related Concept Videos

Obesity01:24

Obesity

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The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
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Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

28
Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH...
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Hyperthyroidism I: Introduction01:25

Hyperthyroidism I: Introduction

30
Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...
30
Graves' Disease I: Introduction01:28

Graves' Disease I: Introduction

23
Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence...
23
Graves Disease II: Pathophysiology01:24

Graves Disease II: Pathophysiology

26
Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor,...
26
Hypothyroidism II: Pathophysiology01:23

Hypothyroidism II: Pathophysiology

26
Hypothyroidism is a disorder characterized by insufficient production of thyroid hormones, which regulate metabolism, energy balance, and multiple organ systems.TypesHypothyroidism is classified based on the level of dysfunction. Primary hypothyroidism results from intrinsic thyroid gland dysfunction, causing reduced hormone production despite normal or increased stimulation. Secondary hypothyroidism arises from inadequate thyroid-stimulating hormone (TSH) secretion by the pituitary. Tertiary...
26

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Related Experiment Video

Updated: May 1, 2026

An Acupoint Catgut-embedding Therapy for Treating Obesity
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Obesity and thyroid cancer.

Marjory Alana Marcello1, Lucas Leite Cunha2, Fernando Assis Batista2

  • 1Laboratory of Cancer Molecular Genetics (Gemoca)Faculty of Medical Sciences, University of Campinas (FCM- Unicamp), Rua Tessália Vieira de Camargo 126, Barão Geraldo, Campinas, São Paulo 13083-970, Brazil marjoryam@gmail.com.

Endocrine-Related Cancer
|April 18, 2014
PubMed
Summary

Obesity is linked to thyroid cancer through factors like hormones and inflammation. Understanding these molecular links is crucial for addressing the rising incidence of both conditions.

Keywords:
molecular biologyobesityoncology

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Area of Science:

  • Endocrinology
  • Oncology
  • Molecular Biology

Background:

  • Observational studies link obesity and thyroid cancer, but molecular mechanisms remain unclear.
  • Rising incidence of both obesity and thyroid cancer necessitates understanding their association.
  • Adipose tissue influences key biological processes relevant to carcinogenesis.

Purpose of the Study:

  • To review and synthesize recent studies on obesity-related factors contributing to thyroid cancer.
  • To elucidate the molecular mechanisms linking obesity to thyroid cancer development and progression.

Main Methods:

  • Literature review of recent studies.
  • Analysis of molecular pathways involving adipose tissue.
  • Identification of key obesity-related factors implicated in thyroid cancer.

Main Results:

  • Obesity influences thyroid cancer via thyroid hormones, insulin resistance, adipokines, inflammation, and sexual hormones.
  • Molecular pathways affected include MAPK, PI3K, insulin signaling, and inflammatory responses.
  • Adipose tissue plays a central role through its involvement in metabolic and inflammatory processes.

Conclusions:

  • Multiple interconnected molecular mechanisms explain the association between obesity and thyroid cancer.
  • Further research into these factors may reveal novel therapeutic targets for thyroid cancer prevention and treatment.
  • Understanding these links is vital for public health strategies addressing the dual epidemic.