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A dorsolateral spinothalamic tract in macaque monkey.

A Vania Apkarian1, Charles J Hodge

  • 1Department of Neurosurgery, State University of New York Health Science Center, 750 East Adams Street, Syracuse, NY 13210 U.S.A.

Pain
|June 1, 1989
PubMed
Summary
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Researchers found a dorsolateral spinothalamic tract in macaque monkeys, similar to pathways in rats and cats. This pathway, involving lamina I cells, ascends to the thalamus and suggests a similar human pathway for pain signaling.

Area of Science:

  • Neuroscience
  • Spinal Cord Anatomy
  • Somatosensory System

Background:

  • Previous studies identified a major spinal cord pathway involving lamina I cell axons in the dorsolateral funiculus in rats and cats.
  • In cats, part of this pathway projects to the thalamus, suggesting a spinothalamic connection.

Purpose of the Study:

  • To investigate the existence and characteristics of a dorsolateral spinothalamic tract in macaque monkeys.
  • To determine the axonal pathways of spinothalamic tract neurons in the macaque spinal cord.

Main Methods:

  • Utilized retrograde transport of horseradish peroxidase (HRP) injected into the somatosensory thalamus of macaque monkeys.
  • Combined HRP injections with ipsilateral thoracic spinal cord lesions (ventral or dorsolateral) to trace axonal trajectories.

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Main Results:

  • Identified numerous lamina I cell axons ascending to the thalamus within the dorsolateral funiculus, contralateral to their origin.
  • Observed that some lamina I axons and most axons from deeper laminae ascend in the contralateral ventral quadrant to reach the thalamus.

Conclusions:

  • Demonstrated the presence of a dorsolateral spinothalamic tract in macaque monkeys, composed of lamina I cell axons.
  • This finding implies a homologous pathway in humans, with significant implications for understanding nociception (pain perception).