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Biochemical Measurement of Neonatal Hypoxia
Published on: August 24, 2011
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Congenital hypothyroidism in neonates
Aneela Anjum1, Muhammad Faheem Afzal1, Syed Muhammad Javed Iqbal1
1Department of Paediatrics, King Edward Medical University/Mayo Hospital, Lahore, Pakistan.
Indian Journal of Endocrinology and Metabolism
|April 18, 2014
Summary
Congenital hypothyroidism (CH) affects 0.8% of neonates, a significant finding for early intervention. Maternal hypothyroidism and drug use during pregnancy are linked to CH development.
Area of Science:
- Pediatrics
- Endocrinology
- Neonatal Health
Background:
- Congenital hypothyroidism (CH) is a leading preventable cause of intellectual disability in children.
- CH occurs in approximately 1 in 2,000 to 1 in 4,000 newborns.
- Early detection and treatment of CH are crucial for neurodevelopmental outcomes.
Purpose of the Study:
- To determine the incidence of congenital hypothyroidism (CH) in neonates.
- To investigate the association between CH and maternal factors.
Main Methods:
- A cross-sectional study was conducted on 550 newborns over six months.
- Thyroid-stimulating hormone (TSH) levels were measured using immunoradiometric assay.
- Data analysis involved SPSS 17 and Chi-square tests.
Main Results:
- The prevalence of CH was found to be 0.8% (4 out of 550 newborns).
- A statistically significant association was observed between CH and maternal hypothyroidism (P=0.000).
- Maternal drug intake during pregnancy also showed a significant association with CH (P=0.013).
Conclusions:
- The incidence of CH in the studied neonate population is 0.8%.
- Maternal hypothyroidism and medication use during pregnancy are significant risk factors for CH.
- These findings underscore the importance of maternal health monitoring during pregnancy.
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