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Pact with the devil: alemtuzumab therapy, immune suppression and infectious complications in chronic lymphocytic

I Antohe, Angela Dascalescu, Cristina Burcoveanu

    Revista Medico-Chirurgicala a Societatii De Medici Si Naturalisti Din Iasi
    |April 19, 2014
    PubMed

    Infectious complications are an important cause of hospitalization in patients diagnosed with chronic lymphocytic leukemia. The pathogenesis of infection is complex, involving both disease-induced and treatment-related immune depression. During the last decade, the management of chronic lymphocytic leukemia (CLL) has been redefined by the approval of monoclonal antibody-based treatment, which resulted in improved therapeutic responses. Nonetheless, the profound lymphopenia induced by monoclonal agents was accompanied by increased incidence of infections caused by a new spectrum of opportunistic microorganisms. We report the case of a patient with hypercellular CLL who received Alemtuzumab as first line therapy and obtained a satisfactory therapeutic response, but developed subsequent atypical infectious complications.

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