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Glucocorticoid therapy for gastrointestinal diseases
1Stanford University School of Medicine, Gastroenterology , 300 Pasteur Drive, Stanford, CA 94305 , USA vagt@stanford.edu.
Expert Opinion on Drug Safety
|April 19, 2014
Summary
Glucocorticoids are vital for treating gastrointestinal diseases but require careful monitoring due to side effects. Newer, safer compounds offer improved tolerability and efficacy in managing these inflammatory conditions.
Area of Science:
- Gastroenterology
- Immunology
- Pharmacology
Background:
- Glucocorticoids are primary treatments for immune-mediated gastrointestinal diseases.
- Undesirable side effects necessitate vigilant monitoring during glucocorticoid therapy.
Purpose of the Study:
- To review glucocorticoid therapy in gastrointestinal diseases.
- To highlight recognition and management of secondary effects.
Main Methods:
- PubMed search of English language literature.
- Focus on key aspects of glucocorticoid therapy and its side effects.
Main Results:
- Clinical efficacy, safety, and tolerability of glucocorticoid therapy have been evaluated.
- Newer compounds with reduced toxicity and improved tolerability are emerging.
- The role of mucosal immunity and microscopic inflammation is under investigation.
Conclusions:
- Glucocorticoid therapy is part of a broader treatment arsenal.
- Safer glucocorticoid compounds show promise for gastrointestinal diseases with altered motility and hypersensitivity.
- Future research will explore the gut microbiota's role in immune responses.
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