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Updated: May 1, 2026

Covalent Attachment of Single Molecules for AFM-based Force Spectroscopy
Published on: March 16, 2020
Dynamic introduction of cell adhesive factor via reversible multicovalent phenylboronic acid/cis-diol polymeric
Guoqing Pan1, Bingbing Guo, Yue Ma
1Orthopedic Institute, Soochow University , 708 Renmin Road, Suzhou, Jiangsu 215007, China.
Abstract:
In this work, dynamic introduction of bioactive RGD peptide on a matrix was successfully demonstrated via reversible multicovalent interactions within PBA/cis-diol polymeric complexes. These reversible, stable multiple interaction sites, in addition to a long accessible polymeric linker, enabled "reversible" control of cell adhesion by specific biomolecular exchange (e.g., glucose or fructose). This biomolecule-triggered, noninvasive strategy shows great promise for use in real-time biological research and mimics natural biomolecular feedback systems, thus having potential application in medical diagnoses and regenerative medicine.
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