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Feasibility of intensity-modulated and image-guided radiotherapy for locally advanced esophageal cancer
Nam P Nguyen1, Siyoung Jang, Jacqueline Vock
1Department of Radiation Oncology, Howard University Hospital, 2401 Georgia Avenue, N,W,, Room 2055, Washington, DC 20060, USA. NamPhong.Nguyen@yahoo.com.
Background:
In this study the feasibility of intensity-modulated radiotherapy (IMRT) and tomotherapy-based image-guided radiotherapy (IGRT) for locally advanced esophageal cancer was assessed.
Methods:
A retrospective study of ten patients with locally advanced esophageal cancer who underwent concurrent chemotherapy with IMRT (1) and IGRT (9) was conducted. The gross tumor volume was treated to a median dose of 70 Gy (62.4-75 Gy).
Results:
At a median follow-up of 14 months (1-39 months), three patients developed local failures, six patients developed distant metastases, and complications occurred in two patients (1 tracheoesophageal fistula, 1 esophageal stricture requiring repeated dilatations). No patients developed grade 3-4 pneumonitis or cardiac complications.
Conclusions:
IMRT and IGRT may be effective for the treatment of locally advanced esophageal cancer with acceptable complications.
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