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Updated: May 1, 2026

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts

Published on: June 13, 2019

[Interdigitating dendritic cell sarcoma/tumor: a clinicopathologic study].

Minhong Pan¹, Qixing Gong¹, Qinhe Fan¹

¹Department of Pathology, the First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China.

Zhonghua Bing Li Xue Za Zhi = Chinese Journal of Pathology

|April 19, 2014

Summary

This summary is machine-generated.

Interdigitating dendritic cell sarcoma/tumor (IDCS/T) is a rare, aggressive cancer. Diagnosis relies on specific histological patterns and S-100 protein/CD68 markers, crucial for differentiating it from other soft tissue tumors.

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Area of Science:

Oncology
Pathology
Immunohistochemistry

Context:

Interdigitating dendritic cell sarcoma/tumor (IDCS/T) is a rare neoplasm.
Understanding its clinicopathologic features is essential for accurate diagnosis.

Purpose:

To elucidate the clinicopathologic characteristics and diagnostic criteria of IDCS/T.
To aid in differentiating IDCS/T from similar entities.

Summary:

Six cases of IDCS/T were analyzed for clinical, histological, and immunohistochemical findings.
Tumor cells positive for S-100 protein and CD68, with characteristic morphology, define IDCS/T.
Involvement sites included lymph nodes, tonsils, and soft tissues.

Impact:

IDCS/T is a rare malignant tumor with a poor prognosis.
Distinctive histological and immunophenotypic profiles aid in diagnosis.
Distinguishing IDCS/T from follicular dendritic cell sarcoma, anaplastic large cell lymphoma, and other spindle cell sarcomas is critical.