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[Histopathological changes in EV71-infected mouse model:a transmission electron microscopic study].

Pin Yu1, Linlin Bao1, Lili Xu1

  • 1Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences & Comparative Medicine Center, Peking Union Medical Collage; Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Beijing 100101, China.

Zhonghua Bing Li Xue Za Zhi = Chinese Journal of Pathology
|April 19, 2014
PubMed
Summary

Enterovirus 71 (EV71) infection causes severe muscle damage and affects the central nervous system in a mouse model. These findings suggest EV71 has a strong affinity for muscle tissue and may cause paralysis through neurological damage.

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Area of Science:

  • Virology
  • Neuropathology
  • Infectious Diseases

Context:

  • Enterovirus 71 (EV71) is a significant human pathogen causing hand, foot, and mouth disease, which can lead to severe neurological complications.
  • Understanding the tissue tropism and pathogenesis of EV71 is crucial for developing effective treatments and preventative strategies.

Purpose:

  • To document the ultrastructural changes in various organs of a mouse model infected with EV71.
  • To investigate the myotropism and pathogenesis of EV71 within the nervous system.

Summary:

  • Mice infected with EV71 exhibited mild brain lesions, including mitochondrial swelling and myelin sheath vacuolation.
  • Anterior motor neurons showed degeneration, with disappearing Nissl bodies and neuronophagia, while skeletal muscles displayed degeneration and myocyte karyopyknosis.
  • Jejunum epithelium showed disrupted microvilli, and lungs developed interstitial pneumonia with type II pneumocyte proliferation.

Impact:

  • The study demonstrates severe myositis in the EV71 mouse model, indicating significant myotropism.
  • Observed lesions in the central nervous system and anterior motor neurons correlate with limb paralysis, highlighting EV71's neurovirulence.