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Spirulina maxima Protects Liver From Isoniazid and Rifampicin Drug Toxicity

Santosh Kumar Jatav1, Archana Kulshrestha1, Anish Zacharia1

  • 11 Jiwaji University, Gwalior, India.

Journal of Evidence-Based Complementary & Alternative Medicine
|April 19, 2014
PubMed

Insights

Spirulina maxima protects against liver damage caused by tuberculosis drugs isoniazid and rifampicin. This natural supplement shows promise for both preventing and treating drug-induced hepatotoxicity.

Area of Science:

  • Pharmacology
  • Hepatology
  • Natural Product Research

Background:

  • Hepatotoxicity from isoniazid and rifampicin is a significant challenge in tuberculosis treatment.
  • Drug-induced liver injury necessitates exploring protective and therapeutic agents.

Purpose of the Study:

  • To evaluate the prophylactic and therapeutic effects of Spirulina maxima against isoniazid and rifampicin-induced hepatotoxicity in a rat model.
  • To assess Spirulina maxima's impact on liver function biomarkers and oxidative stress.

Main Methods:

  • Wistar rats were administered isoniazid and rifampicin to induce hepatic damage.
  • Spirulina maxima was co-administered prophylactically or administered therapeutically to assess its effects.
  • Liver function tests (bilirubin, AST, ALT, ALP) and oxidative stress markers (SOD, catalase, GSH, TBARS) were analyzed.

Main Results:

  • Isoniazid and rifampicin significantly altered liver function and oxidative stress markers.
  • Co-administration of Spirulina maxima protected against drug-induced hepatotoxicity.
  • Therapeutic administration of Spirulina maxima for two weeks normalized liver function markers.

Conclusions:

  • Spirulina maxima demonstrates significant prophylactic and therapeutic potential in mitigating antituberculosis drug-induced hepatotoxicity.
  • Co-administration offers nutritional benefits alongside liver protection.
  • Spirulina maxima is a promising natural agent for managing liver complications in tuberculosis therapy.
Keywords:
hepatotoxicityisoniazidrifampicintuberculosis

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