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Updated: May 1, 2026

Models of Bone Metastasis
Published on: September 4, 2012
Therapeutic strategies for treating osteolytic bone metastases
Elise Verron1, Heidy Schmid-Antomarchi2, Hugues Pascal-Mousselard3
1INSERM U791, Université de Nantes, Faculté de Chirurgie Dentaire, 44042 Nantes, France.
Abstract:
The recent progress in oncologic management of patients with localized cancer or metastatic disease has permitted a significant improvement in life expectancy. Nevertheless, bone metastases and their consequent skeletal-related events (SREs) are still associated with unfavorable prognosis and greatly affect quality of life. Global management of these bone metastases includes traditional local approaches (surgery, radiotherapy, etc.) and systemic administration of chemotherapeutic agents. This review focuses on treatments specific for bone metastases and, in particular, on inhibitors of bone resorption that are effective for preventing and delaying the development of SREs.
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