Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bioreactor Controls-III01:22

Bioreactor Controls-III

67
Strain improvement is a foundational strategy in industrial microbiology aimed at maximizing microbial productivity, particularly because natural isolates typically yield commercially valuable products in very low concentrations. Although optimizing the culture medium and environmental conditions can improve yields, these adjustments are inherently limited by the organism’s genetic potential. As a result, the focus shifts toward genetic modifications to enhance biosynthetic capacity. The...
67
Upstream Processing01:27

Upstream Processing

97
Upstream processing represents a critical phase in biomanufacturing, wherein biological systems such as microorganisms, mammalian cells, or insect cells are cultivated to produce therapeutic proteins, vaccines, enzymes, or other biologically derived products. This phase encompasses all steps from the selection and genetic manipulation of the production organism to the cultivation of cells in bioreactors under tightly controlled environmental conditions.Host Selection and Genetic OptimizationThe...
97
Synthetic Biology02:55

Synthetic Biology

4.4K
Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
4.4K
Production of Pharmaceuticals01:30

Production of Pharmaceuticals

94
Industrial insulin production uses genetically engineered E. coli expressing a proinsulin gene controlled by a tryptophan promoter and containing a methionine linker for later cleavage. The cells also carry ampicillin resistance for selective growth. Seed cultures are stored at −80 °C and production begins by thawing a small amount to inoculate starter cultures, which are progressively scaled to a 50,000-L bioreactor. In the bioreactor, E. coli grow in nutrient-rich media under...
94
Combined Effects of Drugs: Synergism01:27

Combined Effects of Drugs: Synergism

6.2K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
6.2K
Plant Breeding and Biotechnology01:59

Plant Breeding and Biotechnology

17.2K
Crop cultivation has a long history in human civilization, with records showing the cultivation of cereal plants beginning at around 8000 BC. This early plant breeding was developed primarily to provide a steady supply of food.
17.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The energetic costs of escaping predation in wild, schooling white mullet (Mugil curema).

The Journal of experimental biology·2026
Same author

Transcriptional regulatory networks of the human gut symbiont Bacteroides thetaiotaomicron are uncovered using machine learning.

Nucleic acids research·2025
Same author

PMkbase (version 1.0): an interactive web-based tool for tracking bacterial metabolic traits using phenotype microarrays made interoperable with sequence information and visualizing/processing PM data.

Microbiology spectrum·2025
Same author

Dual-cycle CO<sub>2</sub> fixation enhances growth and lipid synthesis in <i>Arabidopsis thaliana</i>.

Science (New York, N.Y.)·2025
Same author

Regulatory orchestration of FK506 biosynthesis in <i>Streptomyces tsukubaensis</i> NRRL 18488 revealed through systematic analysis.

iScience·2025
Same author

CRISPRi screening reveals <i>E. coli</i>'s anaerobic-like respiratory adaptations to gentamicin: membrane depolarization by CpxR.

mSystems·2025

Related Experiment Video

Updated: May 1, 2026

BioMEMS: Forging New Collaborations Between Biologists and Engineers
07:26

BioMEMS: Forging New Collaborations Between Biologists and Engineers

Published on: November 1, 2007

7.8K

Engineering synergy in biotechnology.

Jens Nielsen1, Martin Fussenegger2, Jay Keasling3

  • 11] Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Hørsholm, Denmark. [2] Department of Chemical and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden, and the Science for Life Laboratory, Royal Institute of Technology, Solna, Sweden.

Nature Chemical Biology
|April 19, 2014
PubMed
Summary
This summary is machine-generated.

Biotechnology offers sustainable solutions using metabolic engineering and synthetic biology. These fields create efficient cell factories to convert biomass into valuable fuels, chemicals, and materials.

More Related Videos

High-throughput Identification of Synergistic Drug Combinations by the Overlap2 Method
07:51

High-throughput Identification of Synergistic Drug Combinations by the Overlap2 Method

Published on: May 21, 2018

11.5K
Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow
08:58

Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow

Published on: October 17, 2025

840

Related Experiment Videos

Last Updated: May 1, 2026

BioMEMS: Forging New Collaborations Between Biologists and Engineers
07:26

BioMEMS: Forging New Collaborations Between Biologists and Engineers

Published on: November 1, 2007

7.8K
High-throughput Identification of Synergistic Drug Combinations by the Overlap2 Method
07:51

High-throughput Identification of Synergistic Drug Combinations by the Overlap2 Method

Published on: May 21, 2018

11.5K
Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow
08:58

Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow

Published on: October 17, 2025

840

Area of Science:

  • Biotechnology
  • Sustainable chemistry
  • Industrial biotechnology

Background:

  • Biotechnology is crucial for developing sustainable fuels, chemicals, and materials.
  • Metabolic engineering and synthetic biology are key disciplines within biotechnology.
  • Efficient conversion of biomass feedstocks is a major goal.

Purpose of the Study:

  • To summarize the development of biotechnology.
  • To highlight the roles of metabolic engineering and synthetic biology.
  • To discuss the creation of efficient cell factories.

Main Methods:

  • Review of recent open discussions in the field.
  • Synthesis of information on metabolic engineering approaches.
  • Synthesis of information on synthetic biology approaches.

Main Results:

  • Biotechnology provides sustainable solutions.
  • Metabolic engineering and synthetic biology offer distinct yet complementary strategies.
  • These approaches enable the development of efficient cell factories.

Conclusions:

  • Metabolic engineering and synthetic biology are advancing biotechnology.
  • Cell factories are key to sustainable chemical production.
  • Biomass conversion is a central focus for future materials and fuels.