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Published on: August 2, 2017
Prediction of large-for-gestation neonates with first-trimester maternal serum PAPP-A
A Rossi1, E Vogrig, L Ganzitti
1Department of Obstetrics and Gynecology, University of Udine, Udine, Italy - irenerom@libero.it.
Aim:
The aim of this paper was to identify maternal/pregnancy characteristics, first trimester ultrasound parameters and biochemical indices which are significant independent predictors of large-for-gestational age (LGA) neonates.
Methods:
An Observational cross-sectional study was conducted at the Fetal Medicine Unit, Department of Obstetrics and Gynecology of the University of Udine (Italy). Seventy-two singleton pregnancies presenting for screening for chromosomal abnormalities by nuchal translucency and maternal serum biochemistry at 11-14 weeks. Linear regression was applied to develop first trimester prediction models for LGA.
Results:
Maternal height, parity, smoking, assisted conception and pregnancy-associated plasma protein-A were significant independent predictors of LGA. PAPP-A cut-off value expressed in MoM of 1.25 used for the study was chosen to obtain good sensitivity and specificity values.
Conclusion:
Prediction for birthweight deviations (LGA) is feasible using data available at the routine 11-14 weeks' examination.
