Related Experiment Video

Updated: May 1, 2026

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization
09:57

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization

Published on: September 20, 2024

3.5K

[Long-term outcome and related factors of epileptic seizures in children]

Zhe Tao1, Wen-xia Yi2, Ying Han2

  • 1Deparment of Pediatrics, Peking University First Hospital, Beijing 100034, China; Deparment of Pediatric Neurology, Dalian Children's Hospital, Liaoning Dalian 116012, China.

Beijing Da Xue Xue Bao. Yi Xue Ban = Journal of Peking University. Health Sciences
|April 19, 2014
PubMed

Insights

Long-term epilepsy outcomes in children are generally positive with antiepileptic drug therapy. Seizure freedom rates vary significantly based on epilepsy syndrome type, etiology, and age at onset.

Area of Science:

  • Pediatric Neurology
  • Epileptology

Background:

  • Epilepsy is a chronic neurological disorder affecting millions of children worldwide.
  • Understanding long-term seizure outcomes and prognostic factors is crucial for effective management.

Purpose of the Study:

  • To analyze the long-term seizure outcomes in children with epilepsy.
  • To investigate the influence of age at onset, epileptic syndrome type, and etiology on seizure control.

Main Methods:

  • Retrospective analysis of clinical data from 265 children with epilepsy followed for over one year.
  • Calculation of seizure-free rates (defined as at least one year without seizures).
  • Association analysis between seizure outcomes and various clinical factors.

Main Results:

  • Overall seizure-free rate was 53.6% with regular antiepileptic drug therapy.
  • Higher seizure-free rates were observed in idiopathic generalized epilepsy (72.4%) and benign epilepsy with centro-temporal spikes (65.5%).
  • Infantile spasms had the lowest seizure-free rate (21.7%), and younger age at onset correlated with poorer outcomes.

Conclusions:

  • Regular antiepileptic drug therapy leads to satisfactory seizure outcomes in over half of children with epilepsy.
  • Prognosis is significantly influenced by etiological factors, epilepsy syndrome type, and age at onset.
  • Tailored treatment strategies based on these factors can improve long-term seizure control.
Abstract

More Related Videos

Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy10:22

Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy

Published on: December 6, 2016

22.8K
Author Spotlight: Studying Clinical Characters and Epilepsy Outcomes After Frontal Disconnection in Patients with MOGHE06:04

Author Spotlight: Studying Clinical Characters and Epilepsy Outcomes After Frontal Disconnection in Patients with MOGHE

Published on: August 16, 2024

1.8K

Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
1.7K
Epilepsy ll: Types01:22

Epilepsy ll: Types

Recurrent seizures, stemming from abnormal electrical activity in the brain, are the defining characteristic of epilepsy, a chronic neurological condition. Because seizure features vary greatly, epilepsy is classified using two systems: by seizure type and by epilepsy syndromes. These classifications enable clinicians to describe seizure patterns and select suitable treatment strategies.I. Classification by Seizure Type1. Focal EpilepsyFocal epilepsy begins in one hemisphere of the brain.
47
Seizures l: Introduction01:20

Seizures l: Introduction

Understanding seizures and epilepsy relies on key definitions that help in recognizing, classifying, and managing these disorders. These definitions provide a framework for recognizing, classifying, and managing seizure disorders.DefinitionsA seizure is a sudden, abnormal burst of electrical activity in the brain that can cause changes in awareness, movement, sensation, or behavior, depending on the area involved. Epilepsy is a chronic condition characterized by recurrent, unprovoked seizures,...
42
Seizures: Classification01:13

Seizures: Classification

Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
2.5K
Seizures ll: Types01:19

Seizures ll: Types

Seizures are sudden bursts of abnormal electrical discharge in the brain that interfere with normal function. They are commonly divided into three groups: focal seizures, generalized seizures, and other types that do not fit neatly into either category.Focal SeizuresFocal seizures begin in a single brain region. When awareness is preserved, they are called focal aware seizures and may cause sensations such as tingling, unusual smells, or flashing lights. When awareness is impaired, they are...
36
Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein01:20

Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein

Antiepileptic drugs, such as levetiracetam (Keppra) and brivaracetam (Briviact), have emerged as crucial tools in managing epilepsy. These medications exert their therapeutic effects by targeting the synaptic vesicle protein SV2A, a transmembrane glycoprotein primarily found in the brain.
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
1.2K