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Updated: May 1, 2026
Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line
Published on: September 28, 2022
Acute retinal necrosis associated with Epstein-Barr virus: immunohistopathologic confirmation
Shlomit Schaal1, Aleksandr Kagan1, Yujuan Wang2
1Department of Ophthalmology and Visual Sciences, University of Louisville, Louisville, Kentucky.
Importance:
Acute retinal necrosis (ARN) is an infectious retinitis primarily caused by the herpesviruses. Although the Epstein-Barr virus (EBV) has been implicated as a cause of ARN, to our knowledge, there has been no histopathologic documentation. We report the clinical history and histopathologic confirmation that EBV can cause ARN.
Observations:
Clinical course and histopathology of a patient diagnosed with ARN caused by infection with EBV confirmed by molecular pathology.
Conclusions And Relevance:
Epstein-Barr virus is a recognized cause of intraocular inflammation and has been implicated as a possible cause of ARN. However, to our knowledge, tissue demonstration of EBV in a patient with ARN has not previously been reported. We identified the organism in the necrotic retina of a patient receiving immunosuppression because of idiopathic pulmonary fibrosis.
