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The Association Between JAK2V617F Mutation and Bone Marrow Fibrosis at Diagnosis in Patients with
M Cem Arı1, Deram Büyüktaş2, A Emre Eşkazan3
1İstanbul Training and Research Hospital, Department of Hematology, İstanbul, Turkey.
Objective:
Bone marrow fibrosis is the second most common complication that causes morbidity and mortality inpatients with Philadelphia-negative myeloproliferative neoplasms (MPNs). The aim of this study was to investigate theassociation between JAK2V617F mutation and bone marrow fibrosis at diagnosis in patients with MPNs.
Material And Methods:
In total, 149 patients with MPNs were retrospectively evaluated to determine if there was anassociation between the histological grade of bone marrow fibrosis and JAK2V617F mutation.
Results:
In all, 67.7% of the patients carried the mutated JAK2 gene. The presence of JAK2V617F mutation was notassociated with the occurrence of bone marrow fibrosis (P=0.55) or its grade at diagnosis (P=0.65).
Conclusion:
Molecular mechanisms or genetic defects other than JAK2V617F may underlie the occurrence of bonemarrow fibrosis in patients with MPNs.
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