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Related Concept Videos

Cross-reactivity00:42

Cross-reactivity

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Overview
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Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

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Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum...
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Antigens Involved in Adaptive Immunity01:26

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An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
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Antigen Presenting Cells01:22

Antigen Presenting Cells

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The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
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Antibody Actions01:26

Antibody Actions

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Antibodies, or immunoglobulins, are critical players in the immune system's arsenal against invading pathogens. Produced by B cells and plasma cells, their primary role is to detect and bind to specific antigens, molecules found on the surface of pathogens like bacteria or viruses. Beyond antigen recognition, antibodies perform several vital functions that contribute to immune defense.
Neutralization
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Antigen Processing Pathways01:31

Antigen Processing Pathways

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MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
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Related Experiment Video

Updated: May 1, 2026

Purification of the Membrane Compartment for Endoplasmic Reticulum-associated Degradation of Exogenous Antigens in Cross-presentation
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Antigen cross-presentation of immune complexes.

Barbara Platzer1, Madeleine Stout1, Edda Fiebiger1

  • 1Department of Pediatrics, Division of Gastroenterology and Nutrition, Boston Children's Hospital, Harvard Medical School , Boston, MA , USA.

Frontiers in Immunology
|April 19, 2014
PubMed
Summary

Dendritic cells (DCs) can use IgG immune complexes to cross-present tumor antigens, enhancing cytotoxic T-lymphocyte (CTL) responses. This mechanism involves CD8(-) DCs, broadening therapeutic strategies for cancer immunotherapy.

Keywords:
CD8+ T cell primingDC subset functionsFc receptor-mediated antigen uptakeIgG-complexed antigensanti-tumor immune responsescell type-specific cross-presentation

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Area of Science:

  • Immunology
  • Cancer Biology
  • Cell Therapy

Background:

  • Dendritic cells (DCs) are crucial for initiating anti-tumor cytotoxic T-lymphocyte (CTL) responses via cross-presentation of tumor antigens.
  • Understanding DC cross-presentation mechanisms is vital for developing effective cell-based cancer immunotherapies.
  • Human DC subsets are key targets for these therapies, necessitating detailed characterization of their cross-presentation capabilities.

Purpose of the Study:

  • To elucidate how dendritic cells (DCs) utilize immunoglobulin G (IgG) immune complexes for efficient cross-presentation of tumor antigens.
  • To explore the role of IgG-mediated cross-presentation in inducing robust tumor-specific CTL responses.
  • To review recent advancements in understanding the cross-presentation properties of human DC subsets for therapeutic applications.

Main Methods:

  • Review of existing literature on dendritic cell (DC) cross-presentation pathways.
  • Analysis of antigen form, uptake mechanisms, and DC subpopulations in cross-presentation.
  • Focus on immunoglobulin G (IgG) immune complex-mediated antigen shuttling via Fc-gamma receptors.

Main Results:

  • While CD8α(+) DCs are potent cross-presenters of soluble antigens, IgG immune complexes enable CD8(-) DCs to efficiently cross-present exogenous antigens.
  • IgG-mediated cross-presentation is a well-established pathway for inducing strong CD8(+) T cell responses.
  • Engaging multiple DC subtypes through IgG-complexed antigens may offer a superior strategy for boosting in vivo CTL responses.

Conclusions:

  • Dendritic cells (DCs) effectively use IgG-complexed antigens to induce cytotoxic T-lymphocyte (CTL) responses, expanding the scope of cross-presentation.
  • IgG-mediated cross-presentation by CD8(-) DCs presents a promising avenue for enhancing cancer immunotherapy efficacy.
  • Further characterization of human DC subsets' cross-presentation abilities is critical for advancing cell-based cancer therapies.