Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diabetic Foot Ulcer01:31

Diabetic Foot Ulcer

33
Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory...
33
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

764
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
764
Pulse Assessment Sites01:11

Pulse Assessment Sites

3.5K
Pulse assessment sites are crucial in evaluating a patient's cardiovascular health. By assessing the pulsations of arteries at specific anatomical locations, healthcare professionals can gather valuable information about blood flow, heart rate, and peripheral circulation. Understanding these pulse assessment sites is essential for conducting comprehensive cardiovascular evaluations and monitoring patients' overall health. These sites are strategically chosen due to the accessibility and...
3.5K
Peripheral Artery Disease IV: Nursing Management01:26

Peripheral Artery Disease IV: Nursing Management

702
 The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...
702
Assessment of the Cardiovascular System III: Palpation01:27

Assessment of the Cardiovascular System III: Palpation

1.6K
Palpation involves feeling the body to evaluate texture, size, consistency, and tenderness for assessing cardiovascular health. The following steps are organized in a head-to-toe order:
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above...
1.6K
Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

630
During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
630

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fluid-regulating hormones and plasma volume during 60 days of head-down bed rest with exercise during artificial gravity (BRACE).

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same author

Exercise during artificial gravity preserves cardiorespiratory fitness but not orthostatic tolerance following 60 days of head-down bed rest (BRACE).

Journal of applied physiology (Bethesda, Md. : 1985)·2025
Same author

Author Correction: Increasing seated reaction forces with lower body negative pressure.

NPJ microgravity·2025
Same author

Increasing seated reaction forces with lower body negative pressure.

NPJ microgravity·2025
Same author

Tracheal nodularity and paratracheal soft tissue nodule: post-radioactive iodine treatment changes with peculiar visual and pathologic findings in a case of metastatic follicular variant papillary thyroid carcinoma: a case report.

Journal of medical case reports·2025
Same author

Expanding the Quantum-Limited Gravitational-Wave Detection Horizon.

Physical review letters·2025

Related Experiment Video

Updated: May 1, 2026

High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model
08:16

High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model

Published on: March 16, 2022

3.1K

Increased microvascular flow and foot sensation with mild continuous external compression.

Armando Rosales-Velderrain1, Michael Padilla1, Charles H Choe1

  • 1Department of Orthopaedic Surgery, University of California San Diego, San Diego, California.

Physiological Reports
|April 19, 2014
PubMed
Summary

Mild, continuous pneumatic compression of the lower extremities improved microvascular blood flow (MBF) and foot sensation in both healthy individuals and type 2 diabetic patients. This suggests a potential new treatment for diabetic leg complications.

Keywords:
Blood flowPneumaticcompressionlower limbsensation

More Related Videos

A Novel Non-invasive Method for the Detection of Elevated Intra-compartmental Pressures of the Leg
04:34

A Novel Non-invasive Method for the Detection of Elevated Intra-compartmental Pressures of the Leg

Published on: May 31, 2019

8.6K
Predictive Measurement for Windlass Change in Length and Selected Treatment Outcomes in Chronic Plantar Fasciitis
02:15

Predictive Measurement for Windlass Change in Length and Selected Treatment Outcomes in Chronic Plantar Fasciitis

Published on: March 1, 2024

1.1K

Related Experiment Videos

Last Updated: May 1, 2026

High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model
08:16

High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model

Published on: March 16, 2022

3.1K
A Novel Non-invasive Method for the Detection of Elevated Intra-compartmental Pressures of the Leg
04:34

A Novel Non-invasive Method for the Detection of Elevated Intra-compartmental Pressures of the Leg

Published on: May 31, 2019

8.6K
Predictive Measurement for Windlass Change in Length and Selected Treatment Outcomes in Chronic Plantar Fasciitis
02:15

Predictive Measurement for Windlass Change in Length and Selected Treatment Outcomes in Chronic Plantar Fasciitis

Published on: March 1, 2024

1.1K

Area of Science:

  • Vascular Medicine
  • Diabetology
  • Biomedical Engineering

Background:

  • Peripheral vascular disease and neuropathy are common complications in type 2 diabetes.
  • Compromised microvascular blood flow and reduced foot sensation increase the risk of ulcers and amputations.
  • Current treatments for diabetic lower extremity complications have limitations.

Purpose of the Study:

  • To investigate the effects of mild, continuous pneumatic compression on microvascular blood flow and foot sensation in type 2 diabetic patients.
  • To compare the effects in diabetic patients versus healthy controls.

Main Methods:

  • 19 healthy volunteers and 16 type 2 diabetic patients were recruited.
  • Continuous pneumatic compression (30 mmHg) was applied to the lower extremities for 30 minutes.
  • Skin blood flow (SBF) and muscle blood flow (MBF) were continuously monitored.
  • Foot sensation was assessed before and after compression.

Main Results:

  • Healthy controls showed a significant increase in MBF (39.8%) and foot sensation (49.8%).
  • Type 2 diabetic patients demonstrated a significant increase in MBF (17.7%) and foot sensation (40.2%).
  • Both groups experienced improved MBF and sensation after compression, even counterintuitively.

Conclusions:

  • Mild, continuous pneumatic compression effectively increases microvascular blood flow and improves foot sensation in type 2 diabetic patients.
  • This non-invasive method may offer a novel therapeutic approach for managing diabetic lower extremity complications.
  • Further research is warranted to explore the long-term efficacy and clinical application of this intervention.