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Updated: May 1, 2026

A Comparative Analysis of Recombinant Protein Expression in Different Biofactories: Bacteria, Insect Cells and Plant Systems
Published on: March 23, 2015
Comparative evaluation of recombinant protein production in different biofactories: the green perspective
Matilde Merlin1, Elisa Gecchele1, Stefano Capaldi1
1Department of Biotechnology, University of Verona, 37134 Verona, Italy.
Abstract:
In recent years, the production of recombinant pharmaceutical proteins in heterologous systems has increased significantly. Most applications involve complex proteins and glycoproteins that are difficult to produce, thus promoting the development and improvement of a wide range of production platforms. No individual system is optimal for the production of all recombinant proteins, so the diversity of platforms based on plants offers a significant advantage. Here, we discuss the production of four recombinant pharmaceutical proteins using different platforms, highlighting from these examples the unique advantages of plant-based systems over traditional fermenter-based expression platforms.
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