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Related Concept Videos

Sutures of the Skull01:22

Sutures of the Skull

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The human skull is composed of several bones that come together to protect the brain and support the structures of the face. The junctions where these bones meet are called sutures.
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The superior view of the cranium shows the frontal and paired parietal bones.
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The lateral view of the cranium is dominated by temporal, sphenoid, and ethmoid bones.
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Related Experiment Video

Updated: May 1, 2026

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
08:03

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model

Published on: November 4, 2025

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Altered brain connectivity in sagittal craniosynostosis.

Joel S Beckett1, Eric D Brooks, Cheryl Lacadie

  • 1Department of Neurosurgery, University of California, Los Angeles, California;

Journal of Neurosurgery. Pediatrics
|April 22, 2014
PubMed
Summary

This study found altered brain connectivity in patients with sagittal nonsyndromic craniosynostosis (sNSC). These changes in structural and functional connectivity may explain the executive function deficits common in sNSC.

Keywords:
BA = Brodmann areaDMN = default mode networkDTI = diffusion tensor imagingMNI = Montreal Neurological InstituteNSC = nonsyndromic craniosynostosisROI = region of interestWISC-III = Wechsler Intelligence Scale for Children 3rd editioncraniofacialdefault mode networkdiffusion tensor imagingfunctional connectivityintrinsic connectivitymagnetic resonance imagingrs-fcMRI = resting-state functional connectivity MRIsNSC = sagittal NSCsagittal craniosynostosis

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Area of Science:

  • Neuroimaging
  • Neuroscience
  • Developmental Biology

Background:

  • Sagittal nonsyndromic craniosynostosis (sNSC) is the most common form of craniosynostosis.
  • Over 50% of individuals with sNSC experience executive function deficits.
  • The underlying neurobiological mechanisms for these deficits are not fully understood.

Purpose of the Study:

  • To investigate structural and functional brain connectivity differences in adolescents with sNSC.
  • To determine if these connectivity alterations correlate with neurocognitive deficits.

Main Methods:

  • Diffusion tensor imaging (DTI) and resting-state functional MRI were used.
  • Data were collected from 8 adolescent patients with surgically corrected sNSC and 8 age-matched controls.
  • Analyses were performed using FMRIB Software Library and BioImageSuite.

Main Results:

  • White matter alterations were observed in supratentorial lobes of sNSC patients.
  • Significant differences in mean diffusivity were found in the right supramarginal gyrus.
  • Altered functional connectivity was detected in regions including the prefrontal cortex, anterior cingulate cortex, and default mode network.

Conclusions:

  • The study demonstrates altered neocortical structural and functional connectivity in sNSC.
  • These connectivity changes may partially explain the neuropsychological deficits observed in this population.
  • Larger studies combining multimodal MRI and clinical data are recommended.