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Complex dynamics of compound vesicles in linear flow.

Michael Levant1, Victor Steinberg1

  • 1Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot 76100, Israel.

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|April 22, 2014
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Summary
This summary is machine-generated.

Compound vesicles exhibit complex dynamics in linear flow, including a novel swinging motion. Their behavior in microfluidics offers insights into white blood cell dynamics.

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Area of Science:

  • Biophysics
  • Fluid Dynamics
  • Cellular Mechanics

Background:

  • Unilamellar vesicles are established models for anucleate cells in flow.
  • Understanding compound vesicle dynamics is crucial for advanced cellular modeling.

Purpose of the Study:

  • To experimentally observe and characterize the dynamics of compound vesicles in linear flow.
  • To compare compound vesicle behavior with unilamellar vesicles and explore new dynamical regimes.

Main Methods:

  • Utilizing a microfluidic four-roll mill to generate controlled linear flow.
  • Experimental observation and analysis of compound vesicle behavior under flow conditions.

Main Results:

  • Compound vesicles display tank-treading, trembling (TR), and tumbling regimes, similar to unilamellar vesicles.
  • A novel swinging motion of the inner vesicle was observed during TR, consistent with simulations.
  • Inner and outer vesicles can exhibit synchronized or unsynchronized motions based on the filling factor.

Conclusions:

  • Compound vesicle dynamics are significantly richer and more complex than those of unilamellar vesicles.
  • The observed phenomena provide a basis for using compound vesicles as physical models for white blood cell dynamics.