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Renal excretion of fluoride after fluoride mouth rinses in children

F García-Hoyos1, C Cardososilva2, E Barbería3

  • 1Department of Odontology, Faculty of Biomedical Sciences, European University of Madrid, Spain.

European Journal of Paediatric Dentistry
|April 22, 2014
PubMed

Insights

Fluoride mouth rinses significantly increase urinary fluoride levels in children. This study confirms the effectiveness of fluoride rinses in boosting fluoride excretion post-use.

Area of Science:

  • Pediatric Dentistry
  • Public Health
  • Biochemistry

Background:

  • Fluoride mouth rinses are commonly used for caries prevention.
  • Understanding fluoride absorption and excretion is crucial for safety and efficacy.
  • Limited data exists on short-term urinary fluoride changes in children post-rinse.

Purpose of the Study:

  • To assess the impact of fluoride mouth rinse use on urinary fluoride excretion in children.
  • To quantify the increase in fluoride levels in urine after mouthwash application.

Main Methods:

  • A randomized study involving 58 children (aged 5-8) from non-fluoridated areas.
  • Urine samples collected before and 2 hours after fluoride mouthwash use.
  • Control group (16 children) received no rinse; urinary fluoride/creatinine (F/Cr) ratio analyzed.

Main Results:

  • The mean urinary F/Cr ratio increased from 0.26 mg/g to 1.58 mg/g post-rinse (p<.001).
  • A statistically significant increase of 1.33 mg/g in F/Cr ratio was observed.
  • The control group showed no significant changes in urinary F/Cr ratio (p=0.426).

Conclusions:

  • Fluoride mouthwash use leads to a significant, measurable increase in urinary fluoride excretion in children.
  • This finding supports the direct absorption and subsequent excretion of fluoride from mouth rinse application.
  • The study validates the effectiveness of fluoride rinses in increasing fluoride levels.
Abstract

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