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Synthesis and Reaction Chemistry of Nanosize Monosodium Titanate
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Carbon coated titanium dioxide nanotubes: synthesis, characterization and potential application as sorbents in
M T García-Valverde1, R Lucena1, F Galán-Cano1
1Department of Analytical Chemistry, Institute of Fine Chemistry and Nanochemistry, Marie Curie Building, Campus of Rabanales, University of Córdoba, 14071 Córdoba, Spain.
Journal of Chromatography. A
|April 22, 2014
Summary
Carbon coated titanium dioxide nanotubes (c-TNTs) offer superior extraction performance for naproxen and ketoprofen, especially in acidic conditions. This novel material shows promise for analyzing drugs in biological samples like saliva and urine.
Area of Science:
- Materials Science
- Analytical Chemistry
- Nanotechnology
Background:
- Titanium dioxide nanotubes (TNTs) are widely studied for various applications.
- Developing efficient extraction materials for pharmaceutical analysis is crucial.
- Carbon-based nanomaterials offer unique adsorption properties.
Purpose of the Study:
- To synthesize carbon coated titanium dioxide nanotubes (c-TNTs).
- To evaluate the microextraction performance of c-TNTs for pharmaceutical compounds.
- To develop a method for analyzing naproxen and ketoprofen in biological samples.
Main Methods:
- Hydrothermal synthesis of bare TNTs (b-TNTs) and subsequent caramel coating.
- Thermal treatment in an inert atmosphere to form c-TNTs.
- Characterization using TEM, FTIR, XRD, TGA, and BET analysis.
- Microextraction and liquid chromatography with UV detection (LC-UV).
Main Results:
- c-TNTs exhibited superior extraction efficiency compared to b-TNTs and multiwalled carbon nanotubes (MWCNTs), particularly at low pH.
- c-TNTs demonstrated better dispersibility than MWCNTs, suitable for dispersive micro-solid phase extraction.
- The developed method achieved high recoveries (96-119%) and good precision (<8.5% RSD for urine, <26.3% RSD for saliva).
- Low detection limits were obtained for naproxen and ketoprofen in saliva and urine samples.
Conclusions:
- c-TNTs are effective and promising materials for microextraction applications.
- The proposed method is suitable for the analysis of pharmaceuticals in complex biological matrices.
- The enhanced properties of c-TNTs open avenues for advanced analytical techniques.
Keywords:
Carbon coated titanium dioxide nanotubesDispersive micro-solid phase extractionDrugsMultiwalled carbon nanotubesSalivaUrine
