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Updated: May 1, 2026

Evaluation of a Universal Nested Reverse Transcription Polymerase Chain Reaction for the Detection of Lyssaviruses
Published on: May 2, 2019
Human infection with ORF virus from goats in China, 2012
Keshan Zhang1, Yongjie Liu, Hanjin Kong
1State Key Laboratory of Veterinary Etiological Biology, National Foot and Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute , Chinese Academy of Agricultural Sciences, Lanzhou, China .
Abstract:
Orf virus, which belongs to the Parapoxvirus genus, induces a zoonotic infectious disease characterized by acute, highly vascularized cutaneous pustular lesions in sheep and goats. A number of Orf outbreaks have been reported in sheep and goats in recent years, but no reports have described an Orf virus strain from humans in China. In this study, we diagnosed Orf virus infection in two people, a mother and son, in the Gansu province of China. The human Orf virus was isolated and its phylogenetic characterization was analyzed based on a complete B2L gene. The results are useful for developing prospective programs to control Orf virus infections in both goats and humans.

