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Updated: May 1, 2026

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT
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Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT

Published on: January 7, 2018

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Imaging of Organ Metabolism in Obesity and Diabetes: Treatment Perspectives

J C Hannukainen, M A Guzzardi, K A Virtanen

  • 1Institute of Clinical Physiology, National Research Council (CNR), Via Moruzzi 1, 56124, Pisa, Italy. patricia.iozzo@ifc.cnr.it.

Current Pharmaceutical Design
|April 22, 2014
PubMed

Insights

Imaging organ metabolism helps understand obesity and diabetes complications. This approach aids in identifying therapeutic targets for cardiovascular diseases and heart failure, improving patient outcomes.

Area of Science:

  • Cardiovascular Medicine
  • Metabolic Disorders
  • Medical Imaging

Background:

  • Obesity and diabetes are significant risk factors for cardiovascular diseases (CVD) and heart failure.
  • Understanding the sequence of events from health to these conditions is crucial for effective prevention and treatment.

Purpose of the Study:

  • To review the role of in vivo organ-specific metabolic imaging in understanding the pathogenesis of obesity and diabetes.
  • To highlight how imaging aids in identifying culprits and monitoring treatment responses for cardio-metabolic complications.

Main Methods:

  • Review of advancements in imaging modalities for evaluating organ-specific metabolism in humans.
  • Synthesis of findings from imaging studies on the heart, skeletal muscle, adipose tissue, liver, pancreas, gut, and brain.

Main Results:

  • Imaging advances risk stratification and identifies organ-specific factors in obesity and diabetes.
  • Organ-specific metabolic imaging provides insights into pathogenesis and treatment monitoring for CVD.

Conclusions:

  • Imaging of multiple organs is vital for understanding cardio-metabolic diseases.
  • Emerging areas include cardiac fat, brown adipose tissue conversion, brain's role in energy balance, omics-imaging integration, and gut microbiome metabolism.

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