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Psoriasis patients face higher risks of cardiovascular disease (CVD) and related conditions. Early monitoring and treatment of these comorbidities are crucial for better patient outcomes.

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Area of Science:

  • Dermatology
  • Cardiology
  • Endocrinology

Background:

  • Psoriasis is a chronic inflammatory disease with skin manifestations.
  • It is linked to a significantly increased risk of cardiovascular disease (CVD).
  • Patients with psoriasis often exhibit multiple CVD risk factors and metabolic comorbidities.

Purpose of the Study:

  • To review the associations between psoriasis (and psoriatic arthritis) with CVD.
  • To explore links with vascular risk factors and metabolic diseases.
  • To highlight the impact of treatments on these comorbidities.

Main Methods:

  • This is a narrative review.
  • It synthesizes existing evidence on psoriasis comorbidities.
  • Focuses on proposed underlying mechanisms.

Main Results:

  • Psoriasis patients have higher rates of hypertension, obesity, dyslipidemia, and smoking.
  • Increased prevalence of non-cardiac vascular diseases and metabolic disorders observed.
  • Associations are stronger in severe psoriasis and psoriatic arthritis cases.

Conclusions:

  • Insulin resistance, endothelial dysfunction, and obesity are key linking mechanisms.
  • Treatments targeting CVD risk may improve psoriasis.
  • Physicians must monitor and manage comorbidities in psoriatic patients.