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Antibody humanization methods for development of therapeutic applications

Vahideh Ahmadzadeh1, Safar Farajnia, Mohammad Ali Hosseinpour Feizi

  • 11 Biotechnology Research Center, Tabriz University of Medical Sciences , Tabriz, Iran .

Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
|April 22, 2014
PubMed

Recombinant antibody technologies are rapidly becoming available and showing considerable clinical success. However, the immunogenicity of murine-derived monoclonal antibodies is restrictive in cancer immunotherapy. Humanized antibodies can overcome these problems and are considered to be a promising alternative therapeutic agent. There are several approaches for antibody humanization. In this article we review various methods used in the antibody humanization process.

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