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Antibody humanization methods for development of therapeutic applications
Vahideh Ahmadzadeh1, Safar Farajnia, Mohammad Ali Hosseinpour Feizi
11 Biotechnology Research Center, Tabriz University of Medical Sciences , Tabriz, Iran .
Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
|April 22, 2014
Summary
Murine antibodies cause immune reactions, limiting cancer immunotherapy. Humanized antibodies offer a promising alternative by reducing immunogenicity, making them valuable therapeutic agents.
Area of Science:
- Biotechnology
- Immunology
- Oncology
Background:
- Recombinant antibody technologies show clinical success but face limitations.
- Murine-derived monoclonal antibodies exhibit immunogenicity, restricting their use in cancer immunotherapy.
- Humanized antibodies present a promising alternative to overcome these immunogenicity issues.
Purpose of the Study:
- To review various methods used in antibody humanization.
- To highlight the advantages of humanized antibodies in cancer immunotherapy.
Main Methods:
- Review of existing literature on antibody humanization techniques.
- Analysis of different approaches for creating humanized antibodies.
Main Results:
- Several methods exist for antibody humanization.
- Humanization strategies aim to reduce the immunogenic potential of antibodies.
Conclusions:
- Humanized antibodies are a viable and promising therapeutic strategy in cancer immunotherapy.
- Understanding various humanization methods is crucial for developing effective antibody-based treatments.
