Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dynamics of Dentate Gyrus Place Cells and Dentate Spikes Signal Spatial and Nonspatial Changes in Environments.

bioRxiv : the preprint server for biology·2025
Same author

CA2 neurons show abnormal responses to social stimuli in a rat model of Fragile X syndrome.

bioRxiv : the preprint server for biology·2025
Same author

Hippocampal Place Cell Sequences Are Impaired in a Rat Model of Fragile X Syndrome.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2025
Same author

Social odors drive hippocampal CA2 place cell responses to social stimuli.

Progress in neurobiology·2025
Same author

Hippocampal place cell sequences are impaired in a rat model of Fragile X Syndrome.

bioRxiv : the preprint server for biology·2024
Same author

Social odors drive hippocampal CA2 place cell responses to social stimuli.

bioRxiv : the preprint server for biology·2024

Related Experiment Video

Updated: May 1, 2026

Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice
07:10

Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice

Published on: July 1, 2018

8.5K

Slow and fast γ rhythms coordinate different spatial coding modes in hippocampal place cells.

Kevin Wood Bieri1, Katelyn N Bobbitt2, Laura Lee Colgin1

  • 1Center for Learning and Memory, 1 University Station Stop C7000, The University of Texas at Austin, Austin, TX 78712, USA; Institute for Neuroscience, 1 University Station Stop C7000, The University of Texas at Austin, Austin, TX 78712, USA.

Neuron
|April 22, 2014
PubMed
Summary

The hippocampus uses distinct slow and fast gamma rhythms to manage prospective (retrieval) and retrospective (encoding) memory modes. These alternating states in the CA1 subfield help prevent interference between memory processes.

More Related Videos

Tuning in the Hippocampal Theta Band In Vitro: Methodologies for Recording from the Isolated Rodent Septohippocampal Circuit
11:37

Tuning in the Hippocampal Theta Band In Vitro: Methodologies for Recording from the Isolated Rodent Septohippocampal Circuit

Published on: August 2, 2017

9.4K
Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice
07:33

Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice

Published on: June 29, 2018

11.6K

Related Experiment Videos

Last Updated: May 1, 2026

Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice
07:10

Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice

Published on: July 1, 2018

8.5K
Tuning in the Hippocampal Theta Band In Vitro: Methodologies for Recording from the Isolated Rodent Septohippocampal Circuit
11:37

Tuning in the Hippocampal Theta Band In Vitro: Methodologies for Recording from the Isolated Rodent Septohippocampal Circuit

Published on: August 2, 2017

9.4K
Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice
07:33

Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice

Published on: June 29, 2018

11.6K

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Memory Research

Background:

  • The hippocampus plays a crucial role in memory functions, including encoding and retrieval.
  • Previous research suggested the existence of distinct prospective and retrospective coding modes within the hippocampus.
  • Prospective coding is linked to memory retrieval, while retrospective coding is associated with memory encoding.

Purpose of the Study:

  • To investigate the existence and neural mechanisms of prospective and retrospective coding modes in the hippocampal subfield CA1 in rats.
  • To determine the role of different gamma rhythms (slow and fast) in coordinating neuronal activity during these coding modes.

Main Methods:

  • Electrophysiological recordings in rats to monitor neuronal activity in the hippocampal subfield CA1.
  • Analysis of slow and fast gamma rhythms and their relationship with place cell firing patterns.
  • Examination of ensemble activity during prospective and retrospective coding tasks.

Main Results:

  • Separate prospective and retrospective coding modes were identified in the hippocampal CA1 subfield.
  • Slow gamma rhythms were associated with prospective coding (memory retrieval), showing increased power and spike phase locking.
  • Fast gamma rhythms were associated with retrospective coding (memory encoding), also showing increased power and spike phase locking.
  • Place cells fired earlier in place fields during slow gamma and later during fast gamma.
  • Cell ensembles retrieved upcoming positions during slow gamma and encoded past positions during fast gamma.

Conclusions:

  • Alternating slow and fast gamma states in the hippocampus enable distinct prospective and retrospective coding modes.
  • This mechanism may prevent interference between memory retrieval and encoding processes.
  • The findings provide insights into the neural dynamics underlying memory manipulation in the hippocampus.