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Updated: May 1, 2026

Routine Screening Method for Microparticles in Platelet Transfusions
Published on: January 31, 2018
Thrombosis, platelets, microparticles and PAH: more than a clot
Katie L Lannan1, Richard P Phipps2, R James White3
1Department of Microbiology and Immunology, University of Rochester, 601 Elmwood Ave, Rochester, NY 14642, USA.
Abstract:
Pulmonary arterial hypertension (PAH) is a progressive disease that involves pathological remodeling, vasoconstriction and thrombosis. Alterations in hemostasis, coagulation and platelet activation are consistently observed in PAH patients. Microparticles derived from platelets, inflammatory cells and the endothelium are an increasingly well-recognized signal in a variety of cardiovascular diseases, including PAH. This review will focus on the roles of coagulation, thrombosis, platelet activation and microparticles in the pathology and progression of PAH.
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