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Updated: May 1, 2026

A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology
Published on: March 17, 2016
The age and genomic integrity of neurons after cortical stroke in humans
Hagen B Huttner1, Olaf Bergmann2, Mehran Salehpour3
11] Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden. [2] Department of Neurology, University of Erlangen-Nuremberg, Erlangen, Germany. [3].
Abstract:
It has been unclear whether ischemic stroke induces neurogenesis or neuronal DNA rearrangements in the human neocortex. Using immunohistochemistry; transcriptome, genome and ploidy analyses; and determination of nuclear bomb test-derived (14)C concentration in neuronal DNA, we found neither to be the case. A large proportion of cortical neurons displayed DNA fragmentation and DNA repair a short time after stroke, whereas neurons at chronic stages after stroke showed DNA integrity, demonstrating the relevance of an intact genome for survival.
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