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The distribution of MspI-induced breaks in human lymphocyte chromosomes and its relationship to common fragile sites
B Porfirio1, B Tedeschi, P Vernole
1Department of Public Health and Cell Biology, 2nd University of Rome, Italy.
Mutation Research
|August 1, 1989
Abstract:
The restriction endonuclease MspI (cleavage site C/CGG) induces chromosomal breaks in human lymphocytes. The breakpoints are distributed non-randomly along the chromosomes and the pattern of MspI-induced breakage depends on the recovery time (20 h or 6 h). Chromosomal bands preferentially involved in breakage are likely to coincide with bands where common fragile sites are located.