Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tissue Homogenization and Cell Lysis01:32

Tissue Homogenization and Cell Lysis

9.0K
Tissue homogenization involves disintegrating tissue architecture and lysing cells, and is an early step in isolating and analyzing cellular components. The method used for homogenization depends on the sample type, the amount of sample available, the analyte to be obtained, and the sensitivity of the method. These methods are broadly classified as mechanical and non-mechanical methods.
Mechanical methods of tissue homogenization
These methods rely on applying external physical force to disrupt...
9.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Applicability of methylliberine as a salivary marker under postprandial conditions.

International journal of pharmaceutics: X·2026
Same author

Evidence for the existence of the <i>Magenstrasse</i> and the <i>Darmstrasse</i> when ingesting a caloric solution after a solid meal: A MRI study.

International journal of pharmaceutics: X·2026
Same author

Ventricular free-wall rupture, ventricular pseudoaneurysm, and papillary muscle rupture complicating acute myocardial infarction.

European heart journal·2026
Same author

Ventricular free-wall rupture, ventricular pseudoaneurysm, and papillary muscle rupture complicating acute myocardial infarction.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery·2026
Same author

Aortic reinterventions following reoperative frozen elephant trunk aortic arch replacement for the treatment of residual type A aortic dissection.

JTCVS open·2026
Same author

Current Preclinical and Clinical Evidence of Shock Wave Therapy for Spinal Cord Injury: A Systematic Review.

Cells·2026

Related Experiment Video

Updated: May 1, 2026

Shock Wave Application to Cell Cultures
05:39

Shock Wave Application to Cell Cultures

Published on: April 8, 2014

12.3K

Shock wave application to cell cultures.

Johannes Holfeld1, Can Tepeköylü2, Radoslaw Kozaryn2

  • 1Department of Cardiac Surgery, Innsbruck Medical University; johannes.holfeld@uki.at.

Journal of Visualized Experiments : Jove
|April 22, 2014
PubMed
Summary

Shock waves stimulate cell regeneration without damage. A new model allows shock waves to pass through cell cultures in water, preventing reflections and mimicking in vivo conditions for better mechanotransduction research.

More Related Videos

Evaluating Primary Blast Effects In Vitro
10:51

Evaluating Primary Blast Effects In Vitro

Published on: September 18, 2017

9.4K
A Novel In Vitro Model of Blast Traumatic Brain Injury
08:59

A Novel In Vitro Model of Blast Traumatic Brain Injury

Published on: December 21, 2018

12.9K

Related Experiment Videos

Last Updated: May 1, 2026

Shock Wave Application to Cell Cultures
05:39

Shock Wave Application to Cell Cultures

Published on: April 8, 2014

12.3K
Evaluating Primary Blast Effects In Vitro
10:51

Evaluating Primary Blast Effects In Vitro

Published on: September 18, 2017

9.4K
A Novel In Vitro Model of Blast Traumatic Brain Injury
08:59

A Novel In Vitro Model of Blast Traumatic Brain Injury

Published on: December 21, 2018

12.9K

Area of Science:

  • Biophysics
  • Cell Biology
  • Biomedical Engineering

Background:

  • Shock waves are recognized for their regenerative properties, stimulating cells and tissues without causing damage.
  • In vitro studies are crucial for understanding shock wave effects, but current models often neglect wave behavior post-interaction with cell cultures.

Purpose of the Study:

  • To investigate the behavior of shock waves after passing through cell cultures.
  • To develop an improved in vitro model that minimizes wave reflection and cavitation.
  • To better understand the mechanotransduction process of shock waves in biological systems.

Main Methods:

  • Development of a novel shock wave application model using a Plexiglas container.
  • The model allows shock waves to propagate through cell cultures into a water medium.
  • This design prevents >99% of wave reflection caused by impedance mismatch with air.

Main Results:

  • The developed model successfully prevents significant shock wave reflection at the cell culture-air interface.
  • Elimination of reflections and cavitation provides a more accurate simulation of in vivo conditions.
  • The model facilitates the study of how physical shock wave stimuli translate into biological cell signals (mechanotransduction).

Conclusions:

  • The novel Plexiglas container model offers a superior method for in vitro shock wave research.
  • It enables more accurate investigation of shock wave-induced mechanotransduction by mimicking in vivo environments.
  • This advancement is key to further understanding the regenerative potential of shock waves.