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c-kit mRNA expression in human and murine hematopoietic cell lines
C André1, L d'Auriol, C Lacombe
1Laboratoire d'Hématologie Expérimentale (UPR 41 CNRS 'Recombinaisons Génétiques'), Hôpital Saint-Louis, Paris, France.
Oncogene
|August 1, 1989
Summary
The c-kit proto-oncogene, a tyrosine kinase receptor, is expressed in early human and mouse erythroid and myeloid cells. This suggests c-kit plays a role in early hematopoietic differentiation.
Area of Science:
- Hematology
- Molecular Biology
- Oncology
Background:
- The c-kit proto-oncogene is part of the tyrosine kinase receptor family.
- Evidence suggests c-kit involvement in hematopoiesis, but its ligand remains unidentified.
Purpose of the Study:
- To investigate c-kit mRNA expression in human and murine hematopoietic cells.
- To determine lineage and differentiation specificity of c-kit expression.
Main Methods:
- Studied c-kit mRNA expression in human and murine hematopoietic organs and cell lines.
- Analyzed expression patterns across different hematopoietic lineages.
Main Results:
- c-kit mRNA expression was detected in early erythroid and myeloid differentiation stages.
- No c-kit expression was observed in the lymphoid lineage.
Conclusions:
- c-kit appears to be involved in early erythroid and myeloid differentiation.
- Results suggest a potential role for c-kit as a receptor in early hematopoiesis.