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Updated: May 1, 2026

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Published on: June 2, 2014
Tackling chronic migraine: current perspectives
1Neurology Department, Raigmore Hospital, Inverness, UK; Universitat Internacional de Catalunya, Barcelona, Spain.
Chronic migraine (CM) affects 1%-3% globally, characterized by headaches on 15+ days/month. Effective management involves addressing risk factors, comorbidities, and utilizing treatments like topiramate and cognitive-behavioral therapy.
Area of Science:
- Neurology
- Headache Medicine
Background:
- Chronic migraine (CM) diagnostic criteria have evolved, with the latest revision in the International Classification of Headache Disorders-3 beta.
- CM is defined by headache frequency (≥15 days/month for >3 months) with migraine features (≥8 days/month).
- Concurrent diagnoses of CM and medication-overuse headache are common and require integrated management.
Purpose of the Study:
- To summarize the current understanding of chronic migraine diagnosis, prevalence, risk factors, comorbidities, and management strategies.
- To highlight the impact of CM on quality of life and associated disabilities.
Main Methods:
- Review of diagnostic criteria and epidemiological data for chronic migraine.
- Identification of modifiable risk factors and common comorbidities associated with CM.
- Summary of evidence-based management and treatment options for CM.
Main Results:
- Global prevalence of CM ranges from 1% to 3%, with an annual incidence of 2.5%.
- Modifiable risk factors include medication overuse, obesity, and stress; comorbidities include chronic pain and psychiatric disorders.
- Effective treatments include topiramate, amitriptyline, onabotulinumtoxinA, and cognitive-behavioral therapy.
Conclusions:
- Effective chronic migraine management requires a multi-faceted approach, including risk factor modification and treatment of comorbidities.
- Evidence-based pharmacologic and non-pharmacologic therapies demonstrate efficacy in managing chronic migraine.
- Improved diagnostic criteria and targeted interventions are crucial for reducing the burden of chronic migraine.
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