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Glycemic control indicators in patients with neonatal diabetes mellitus

Shigeru Suzuki1, Masafumi Koga1

  • 1Shigeru Suzuki, Department of Pediatrics, Asahikawa Medical University, Asahikawa 078-8510, Hokkaido, Japan.

World Journal of Diabetes
|April 22, 2014
PubMed

Insights

Glycated albumin (GA) can indicate glycemic control in neonatal diabetes mellitus (NDM). However, increased albumin metabolism in NDM requires adjustments for accurate GA measurements in neonates.

Area of Science:

  • Endocrinology
  • Neonatology
  • Metabolic Disorders

Background:

  • Neonatal diabetes mellitus (NDM) is a rare genetic disorder requiring insulin therapy.
  • Hemoglobin A1c (HbA1c) is unsuitable for glycemic control monitoring in neonates due to high fetal hemoglobin (HbF).
  • Glycated albumin (GA) is an alternative glycemic marker unaffected by HbF.

Purpose of the Study:

  • To review recent findings on glycemic control indicators in neonatal diabetes mellitus.
  • To address challenges in using Glycated Albumin (GA) for monitoring NDM.

Main Methods:

  • Review of current literature on neonatal glycemic control.
  • Analysis of factors affecting Glycated Albumin (GA) levels in NDM.

Main Results:

  • Glycated albumin (GA) shows potential as a glycemic control indicator in NDM.
  • Increased albumin metabolism in NDM leads to underestimated GA levels relative to plasma glucose.
  • Further research is needed to establish reliable methods for GA measurement in NDM.

Conclusions:

  • Glycated albumin (GA) is a promising, yet currently imperfect, indicator for neonatal diabetes mellitus (NDM) management.
  • Adjustments are necessary to accurately interpret GA levels due to altered albumin metabolism in NDM.
  • Developing standardized protocols for GA monitoring is crucial for effective NDM treatment.

Keywords:
1,5-anhydroglucitolFructosamineGlycated albuminGlycemic controlHbA1cNeonatal diabetes mellitus

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