Cromer-related antigens--blood group determinants on decay-accelerating factor

Related Experiment Video

Updated: Aug 13, 2026

FSL Constructs: A Simple Method for Modifying Cell/Virion Surfaces with a Range of Biological Markers Without Affecting their Viability
09:38

FSL Constructs: A Simple Method for Modifying Cell/Virion Surfaces with a Range of Biological Markers Without Affecting their Viability

Published on: August 5, 2011

G Daniels1

  • 1Medical Research Council Blood Group Unit, London, UK.

Vox Sanguinis
|January 1, 1989
PubMed

Insights

Cromer-related antigens are inherited variants of decay-accelerating factor (DAF). The Inab phenotype, lacking these antigens, indicates an inherited DAF deficiency in red blood cells.

Area of Science:

  • Immunogenetics
  • Hematology
  • Complement System Biology

Background:

  • Cromer-related antigens are a group of blood group antigens with shared serological characteristics.
  • These antigens are phenotypically linked and previously lacked a clear molecular basis.

Purpose of the Study:

  • To identify the molecular carrier of Cromer-related antigens.
  • To investigate the genetic basis of the Inab blood group phenotype.

Main Methods:

  • Serological characterization of blood group antigens.
  • Immunochemical analysis to identify protein expression on red blood cells.

Main Results:

  • Cromer-related antigens are confirmed to be carried on decay-accelerating factor (DAF), a complement regulatory glycoprotein.
  • The Inab phenotype, defined by the absence of all Cromer-related antigens, is associated with a deficiency of DAF.

Conclusions:

  • Cromer-related antigens represent inherited variants and polymorphisms of DAF.
  • The Inab phenotype is characterized as an inherited DAF deficiency, providing a molecular explanation for this blood group.

More Related Videos

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment07:26

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

Published on: July 18, 2017

Measuring Erythrocyte Complement Receptor 1 Using Flow Cytometry07:20

Measuring Erythrocyte Complement Receptor 1 Using Flow Cytometry

Published on: May 19, 2020

Related Concept Videos

Blood Types02:20

Blood Types

Human blood is classified into different types based on the presence of antigens on the red blood cell's surface and antibodies in the plasma. Proper identification of blood type is essential for successful blood transfusion. The International Society of Blood Transfusion has identified 38 human blood types based on the surface antigens on the red blood cells. The most common types are ABO, Rh, and MNS blood types.
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
Exon Recombination02:32

Exon Recombination

The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
Exon shuffling follows “splice frame rules.” Each exon has three reading...
The ABO Blood Group01:12

The ABO Blood Group

The ABO blood group system is a critical element of transfusion medicine, essential for determining blood compatibility in transfusions and organ transplants. It is based on specific antigens, or agglutinogens, present on the surface of red blood cells (RBCs) and corresponding antibodies, or agglutinins, in the blood plasma.
Antigens in the ABO Blood Group System
Antigens are substances that can trigger an immune response, leading to the production of antibodies. In the ABO blood group system,...
Rh Blood Group01:19

Rh Blood Group

The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
Blood Typing01:10

Blood Typing

Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target antigens A,...