Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

1.1K
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
1.1K
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

1.2K
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
1.2K
Working Memory01:24

Working Memory

1.3K
Working memory refers to a combination of components, including short-term memory and attention, that allow an individual to hold information temporarily as we perform cognitive tasks. It is an essential cognitive function that enables the execution of complex tasks such as problem-solving, comprehension, and reasoning. Unlike short-term memory, which simply involves the storage of information for a brief period, working memory involves the active manipulation and processing of this...
1.3K
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

2.5K
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
2.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Toward a Pluralistic Model for the Schizophrenia Spectrum-Dopamine and Beyond.

JAMA psychiatry·2026
Same author

The Future of <i>DSM</i>: Response to Letters.

The American journal of psychiatry·2026
Same author

Distinct Connectivity Signatures of Hallucinatory Experiences and Neuromelanin Signal in Adolescents.

medRxiv : the preprint server for health sciences·2026
Same author

Spectrotemporal signatures of driving and modulatory circuits across cortical and subcortical networks.

bioRxiv : the preprint server for biology·2026
Same author

Q-MRS: Quantitative Magnetic Resonance Spectral Analysis Using Deep Learning.

NMR in biomedicine·2026
Same author

Reconsidering the glutamate hypothesis of obsessive-compulsive disorder: A systematic review of proton magnetic resonance spectroscopy studies in unmedicated participants.

Journal of mood and anxiety disorders·2026

Related Experiment Video

Updated: May 1, 2026

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
05:14

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

4.2K

GABA level, gamma oscillation, and working memory performance in schizophrenia.

Chi-Ming A Chen1, Arielle D Stanford2, Xiangling Mao3

  • 1Department of Psychology, University of Connecticut, 406 Babbidge Road, Storrs, CT 06269, USA.

Neuroimage. Clinical
|April 22, 2014
PubMed
Summary

Schizophrenia patients show impaired working memory and reduced gamma oscillations. However, both patients and controls demonstrate a strong link between GABA levels and gamma oscillations, suggesting GABA

Keywords:
Dorsolateral prefrontal cortexGABAGamma oscillationMagnetic resonance spectroscopySchizophreniaWorking memory

More Related Videos

Generation of Local CA1 &#947; Oscillations by Tetanic Stimulation
08:02

Generation of Local CA1 γ Oscillations by Tetanic Stimulation

Published on: August 14, 2015

8.5K
Author Spotlight: Studying Drug Impacts on Brain Signals Using Dual LFP Recording Protocol in Mice
04:44

Author Spotlight: Studying Drug Impacts on Brain Signals Using Dual LFP Recording Protocol in Mice

Published on: February 16, 2024

2.2K

Related Experiment Videos

Last Updated: May 1, 2026

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
05:14

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

4.2K
Generation of Local CA1 &#947; Oscillations by Tetanic Stimulation
08:02

Generation of Local CA1 γ Oscillations by Tetanic Stimulation

Published on: August 14, 2015

8.5K
Author Spotlight: Studying Drug Impacts on Brain Signals Using Dual LFP Recording Protocol in Mice
04:44

Author Spotlight: Studying Drug Impacts on Brain Signals Using Dual LFP Recording Protocol in Mice

Published on: February 16, 2024

2.2K

Area of Science:

  • Neuroscience
  • Psychiatry
  • Biophysics

Background:

  • Working memory deficits, disordered neuronal oscillations, and abnormal prefrontal GABAergic function are hypothesized in schizophrenia.
  • Previous research has not directly compared in vivo GABA levels and gamma band neural synchrony in schizophrenia.

Purpose of the Study:

  • To investigate the relationship between working memory performance, neuronal oscillations (gamma band), and GABA levels in the dorsolateral prefrontal cortex (DLPFC) in schizophrenia.
  • To compare these measures between patients with schizophrenia and healthy controls.

Main Methods:

  • A case-control pilot study involving 24 participants (schizophrenia patients and controls).
  • High-density electroencephalograms (EEGs) were used to measure neuronal oscillations during a working memory task.
  • Magnetic resonance spectroscopy (MRS) was employed for in vivo measurement of GABA levels in the left DLPFC.

Main Results:

  • Schizophrenia patients exhibited significantly lower working memory performance compared to controls.
  • Patients showed significantly lower gamma oscillation amplitudes during the working memory task.
  • Significant correlations were found between gamma oscillation amplitude and left DLPFC GABA levels at rest and during the task.
  • Peak gamma frequency during memory encoding correlated with GABA level and working memory performance.

Conclusions:

  • Despite gamma band deficits in schizophrenia, GABA levels critically influence gamma oscillations in both patients and controls.
  • These findings highlight the crucial role of GABAergic function in regulating gamma band activity, even amidst cognitive impairments.
  • GABAergic function may be a key factor in the neural synchrony deficits observed in schizophrenia.