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Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer
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Innovative personalized medicine in gastric cancer: time to move forward

J Lee1, K-M Kim, W K Kang

  • 1Department of Medicine, Division of Hematology-Oncology, Samsung Medical Center,Sungkyunkwan University School of Medicine, Seoul, South Korea.

Clinical Genetics
|April 23, 2014
PubMed

Insights

Gastric cancer (GC) is a leading cause of death. Trastuzumab plus chemotherapy improved survival for HER2-positive GC, and genomic profiling may reveal more patients for targeted therapies.

Area of Science:

  • Oncology
  • Gastroenterology
  • Genetics

Background:

  • Gastric cancer (GC) is a significant global health burden, ranking as the second leading cause of cancer-related mortality worldwide.
  • Despite extensive research, targeted therapy options for GC have shown limited success, with only one trial demonstrating survival benefits in a specific patient subgroup.

Purpose of the Study:

  • To review current targeted therapy clinical trials in gastric cancer.
  • To discuss the potential of actionable driver mutations for future targeted treatments in GC.

Main Methods:

  • Comprehensive literature review of targeted therapy trials in gastric cancer.
  • Analysis of genomic profiling data and its implications for personalized medicine in GC.

Main Results:

  • The addition of trastuzumab to fluoropyrimidine/platinum chemotherapy demonstrated an overall survival (OS) benefit in first-line treatment for human epidermal growth factor receptor 2 (HER2)-positive GC patients.
  • Next-generation sequencing approaches are increasingly identifying patients with specific genomic alterations who may benefit from targeted agents.

Conclusions:

  • Trastuzumab represents a successful targeted therapy for a subset of HER2-positive GC patients.
  • Genomic profiling holds promise for expanding targeted therapy options and improving outcomes in gastric cancer by identifying novel actionable mutations.
Keywords:
actionable mutationschemotherapygastric cancermolecularly targeted agentspersonalized medicine

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