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Conjunctival keratinisation, an abnormal reaction to an ocular beta-blocker
D Derous1, R J de Keizer, D de Wolff-Rouendaal
1Department of Ophthalmology, University Hospital, Leiden, The Netherlands.
Acta Ophthalmologica
|June 1, 1989
Summary
Local beta-blocker metipranolol caused conjunctival leucoplakia. Treatment with all-trans retinoic acid resolved the condition, suggesting metipranolol may act as an antigen.
Area of Science:
- Ophthalmology
- Dermatology
- Pharmacology
Background:
- Beta-blockers are commonly used for ocular conditions.
- Conjunctival leucoplakia is a rare keratinization disorder.
- Practolol, a related drug, has known toxicity.
Observation:
- A patient developed conjunctival leucoplakia after topical metipranolol use.
- The condition resolved upon discontinuation of metipranolol.
- Application of all-trans retinoic acid facilitated the resolution of keratinization.
Findings:
- Topical metipranolol can induce conjunctival leucoplakia.
- Metipranolol shares pharmacological similarities with practolol.
- Metipranolol may function as an antigen, triggering an immune response.
Implications:
- Metipranolol should be used with caution in ocular treatments.
- Further research is needed to understand metipranolol's antigenic potential.
- All-trans retinoic acid shows promise in treating drug-induced conjunctival keratinization.