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Relationship between insulin sensitivity and bone mineral density in primary hyperparathyroidism
Laura Gianotti1, Francesco Tassone, Claudia Baffoni
1Division of Endocrinology, Department of Internal Medicine, S.Croce & Carle Hospital, Cuneo, Italy.
Clinical Endocrinology
|April 23, 2014
Summary
In primary hyperparathyroidism (PHPT), insulin levels and sensitivity show a weak association with bone mineral density (BMD). Post-surgery, insulin status does not impact changes in bone density.
Area of Science:
- Endocrinology
- Metabolic Bone Disease
Background:
- Crosstalk between bone and insulin metabolism is established.
- Limited data exist on this relationship in primary hyperparathyroidism (PHPT).
Purpose of the Study:
- To investigate the association between insulin levels or sensitivity and bone mineral density (BMD) in patients with PHPT.
- To assess if insulin status influences BMD changes after parathyroidectomy (PTX).
Main Methods:
- Studied 267 PHPT patients without diabetes, measuring fasting glucose, insulin, and BMD.
- Assessed insulin sensitivity using the Quantitative Insulin Sensitivity Check Index (QUICKI).
- Re-evaluated parameters in 51 patients after parathyroidectomy (PTX).
Main Results:
- Univariate analysis revealed a weak positive link between insulin levels and femoral neck BMD/T-score.
- Insulin sensitivity (QUICKI) showed a weak negative correlation with femoral BMD/T-score.
- Multivariate analysis identified age, BMI, PTH, and QUICKI as independent predictors of femoral BMD; insulin and QUICKI did not change post-PTX.
Conclusions:
- A weak relationship exists between insulin status and BMD in PHPT.
- Insulin levels and sensitivity do not affect BMD changes following parathyroidectomy in PHPT patients.
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