Related Experiment Video

Updated: May 1, 2026

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography
07:11

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography

Published on: October 28, 2020

2.8K

Relationship of electrocardiographic left ventricular hypertrophy to the presence of diastolic dysfunction

Joseph M Krepp1, Fay Lin, James K Min

  • 1Greenberg Division of Cardiology.

Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc
|April 23, 2014
PubMed

Insights

Electrocardiogram left ventricular hypertrophy (LVH) is a strong predictor of left ventricular diastolic dysfunction (DD). This finding holds true even after accounting for other risk factors and ECG variables, highlighting its clinical significance.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Electrocardiography

Background:

  • Left ventricular (LV) diastolic dysfunction (DD) is a significant predictor of adverse cardiovascular outcomes.
  • The relationship between ECG-detected LV hypertrophy (LVH) and LV DD remains incompletely understood.
  • While LVH is linked to systolic dysfunction, its association with diastolic dysfunction requires further elucidation.

Purpose of the Study:

  • To investigate the association between ECG-detected LVH, specifically using the Cornell product (CP) criteria, and the presence of LV diastolic dysfunction (DD).
  • To determine if ECG LVH is an independent predictor of LV DD.
  • To assess the predictive value of CP for LV DD in a clinical cohort.

Main Methods:

  • A cohort of 185 patients underwent cardiac computed tomographic angiography and transthoracic echocardiography.
  • Diastolic function was comprehensively evaluated using mitral inflow velocities, tissue Doppler imaging, and other relevant parameters.
  • ECG LVH was assessed using Cornell product (CP) criteria.

Main Results:

  • 57% of the patients exhibited LV diastolic dysfunction (DD).
  • Patients in the highest quartile of CP (≥1595 mm·ms) had a significantly greater odds of DD (OR 5.1, P < 0.001).
  • Multivariate analysis confirmed that the highest CP quartile remained a strong predictor of DD (OR 5.9, P = 0.001), with each SD increase in CP also associated with increased DD odds (OR 1.7, P = 0.005).

Conclusions:

  • Cornell product (CP) defined LVH is a robust predictor of left ventricular diastolic dysfunction (DD).
  • This association persists even after adjusting for other clinical and ECG-related risk factors.
  • ECG LVH, particularly via CP criteria, may serve as a valuable non-invasive marker for identifying patients at risk for DD.
Abstract

Keywords:
diastolic dysfunctionelectrocardiographyheart failurehypertrophy

More Related Videos

Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats08:09

Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats

Published on: December 13, 2019

24.4K
Evaluation of Left Ventricular Structure and Function using 3D Echocardiography06:34

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Published on: October 28, 2020

4.1K

Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
805
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1.9K
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
790
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
1.3K
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
1.2K
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
1.8K