Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

1.4K
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
1.4K
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

926
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
926
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

827
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
827
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

64.7K
Overview
64.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Variation in suppression of black-grass by modern and ancestral cereal root exudates.

Plant biology (Stuttgart, Germany)·2025
Same author

War exposure, daily stressors, and mental health 15 years on: implications of an ecological framework for addressing the mental health of conflict-affected populations.

Epidemiology and psychiatric sciences·2024
Same author

<i>Escherichia coli</i> ST117: exploring the zoonotic hypothesis.

Microbiology spectrum·2024
Same author

Accessible and reliable neurometric testing in humans using a smartphone platform.

Scientific reports·2023
Same author

RASA2 a new gatekeeper for TCR signaling.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2022
Same author

First Report of Curvularia Leaf Spot of Field Corn, Caused by <i>Curvularia lunata</i>, in Mississippi.

Plant disease·2022

Related Experiment Video

Updated: May 1, 2026

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
08:38

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS

Published on: November 8, 2015

16.1K

Generic tacrolimus in solid organ transplantation.

D Taube1, G Jones, J O'Beirne

  • 1Imperial College Academic Health Science Centre, London, UK.

Clinical Transplantation
|April 23, 2014
PubMed
Summary
This summary is machine-generated.

Generic tacrolimus, including Sandoz, offers a bioequivalent and safe alternative to innovator drugs for solid organ transplant patients. This cost-effective option demonstrates clinical utility in various transplant types.

Keywords:
bioequivalenceconversionde novoefficacygenericheartkidneyliversafetytacrolimus

More Related Videos

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
11:49

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation

Published on: May 2, 2013

15.5K
Surgical Angiogenesis in Porcine Tibial Allotransplantation: A New Large Animal Bone Vascularized Composite Allotransplantation Model
10:31

Surgical Angiogenesis in Porcine Tibial Allotransplantation: A New Large Animal Bone Vascularized Composite Allotransplantation Model

Published on: August 13, 2017

7.0K

Related Experiment Videos

Last Updated: May 1, 2026

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
08:38

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS

Published on: November 8, 2015

16.1K
Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
11:49

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation

Published on: May 2, 2013

15.5K
Surgical Angiogenesis in Porcine Tibial Allotransplantation: A New Large Animal Bone Vascularized Composite Allotransplantation Model
10:31

Surgical Angiogenesis in Porcine Tibial Allotransplantation: A New Large Animal Bone Vascularized Composite Allotransplantation Model

Published on: August 13, 2017

7.0K

Area of Science:

  • Pharmacology
  • Transplantation Medicine
  • Drug Development

Background:

  • Immunosuppressive therapy is crucial for solid organ transplantation (SOT) success.
  • High costs of innovator immunosuppressants necessitate affordable alternatives.
  • Generic drug development aims to provide equivalent quality, safety, and efficacy.

Purpose of the Study:

  • To review the evidence supporting generic tacrolimus formulations for SOT patients.
  • To highlight the bioequivalence and clinical experience of generic tacrolimus, specifically Sandoz.

Main Methods:

  • Review of available data on generic tacrolimus brands (Intas, PharOS, Sandoz).
  • Focus on bioequivalence studies for generic tacrolimus (Sandoz) compared to innovator tacrolimus (Prograf).
  • Analysis of clinical experience in de novo and conversion settings across different SOT types.

Main Results:

  • Bioequivalence demonstrated for generic tacrolimus (Sandoz) in healthy volunteers and kidney transplant recipients.
  • Clinical data supports the use of generic tacrolimus (Sandoz) in kidney and liver transplant patients.
  • Experience extends to conversion therapy in lung and heart transplant recipients.

Conclusions:

  • Generic tacrolimus formulations, like Sandoz, provide a bioequivalent and clinically viable option for SOT management.
  • The availability of generic tacrolimus can improve patient access to essential immunosuppression.
  • Further clinical data supports the use of generic tacrolimus in diverse SOT populations.