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Updated: May 1, 2026

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
Management of squamous cell vulvar cancer: a review
Gunter Deppe1, Ismail Mert, Ira S Winer
1Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan, USA; Division of Gynecologic Oncology, Wayne State University, Detroit, Michigan, USA.
Abstract:
Squamous cell vulvar cancer is a rare gynecologic malignancy. Standard treatment for early stage disease consists of wide radical excision of the primary tumor with inguinal-femoral lymphadenectomy or sentinel lymph node mapping/biopsy. Because of the general paucity of patients with advanced vulvar cancer, there is no standard therapy for advanced disease and therefore treatment should be individualized. Intergroup trials are needed to clarify the value of chemoradiation, neoadjuvant chemotherapy and targeted therapy in patients with advanced squamous cell cancer of the vulva to identify modalities with the best therapeutic index and lowest morbidity.
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