Related Experiment Video
Updated: May 1, 2026
Mechanical Control of Relaxation Using Intact Cardiac Trabeculae
Published on: February 17, 2023
The trabecula septomarginalis (Leonardo's cord) in abnormal ventriculo-arterial connections: anatomic and
1Paediatric Hospital Gatien de Clocheville CHRU Tours, Paediatric Cardiac Surgery, 49 Boulevard Béranger, 37044 Tours cedex 9, France. capathos@hotmail.com.
Insights
Abnormal ventriculo-arterial connections involve a counter-clockwise rotation of the trabecula septomarginalis. This anatomical finding suggests early cardio-genesis myocardial processes may underlie these congenital heart defects.
Area of Science:
- Cardiovascular Anatomy
- Congenital Heart Disease Research
- Developmental Biology
Background:
- Abnormal ventriculo-arterial connections encompass a spectrum of congenital heart defects, including tetralogy of Fallot and transposition of great arteries.
- The infundibular septum and trabecula septomarginalis are key anatomical landmarks for analyzing these malformations.
- Existing research indicates a pathological counter-clockwise rotation of the infundibular septum in these conditions.
Purpose of the Study:
- To investigate the anatomical evidence of simultaneous abnormal counter-clockwise rotation of the trabecula septomarginalis.
- To analyze the spatial relationship between the trabecula septomarginalis and the infundibular septum in various ventriculo-arterial malformations.
Main Methods:
- Examination of anatomical specimens exhibiting malposition of great arteries.
- Documentation of progressive counter-clockwise rotation (0° to 180°) of the trabecula septomarginalis plane.
Main Results:
- Categorization of malformations based on the posterior limb of the trabecula septomarginalis's commitment to either the ventriculo infundibular fold or the infundibular septum.
- Observed sequential commitment patterns in conditions like tetralogy of Fallot, double outlet right ventricle, and transposition of great arteries.
Conclusions:
- Sequential-segmental analysis effectively identifies diverse cardiac morphologies.
- The trabecula septomarginalis plane exhibits a progressive counter-clockwise twist along the long axis.
- These findings support a hypothesis linking abnormal ventriculo-arterial connections to pathological myocardial processes during early cardiogenesis.
Background:
The abnormal ventriculo-arterial connections in atrio-ventricular concordance and situs solitus with two well developed ventricles include the range from tetralogy of Fallot throughout the different forms of double outlet right ventricle to transposition of great arteries.The infundibular septum and the trabecula septomarginalis are the fundamental anatomical landmarks for the segmental analysis.In these abnormalities there is a pathological progressive counter-clockwise rotation of the infundibular septum which divorces from the antero-superior limb of the trabecula septomarginalis and achieves his identity. Is there any anatomical evidence of a simultaneous abnormal counter-clockwise rotation of the trabecula septomarginalis?
Methods:
Malposition of great arteries is a generic term since all relationships have to be expected.We present specimens with anatomical evidence of a progressive counter-clockwise rotation from 0° to about 180°of the plane passing throughout the trabecula septomarginalis's limbs.
Results:
We can observe sequentially:1. Malformations in which the posterior limb of the trabecula septomarginalis is committed to the ventriculo infundibular fold: (tetralogy of Fallot, double outlet right ventricle with sub-aortic ventricular septal defect, truncus arteriosus and doubly committed ventricular septal defect);2. Malformations in which the posterior limb of the trabecula septomarginalis is committed to the infundibular septum (double outlet right ventricle with sub-pulmonary ventricular septal defect, transposition of great arteries).
Conclusions:
1. The sequential-segmental analysis identify all the morphologies.2. The trabecula septomarginalis plane presents a progressive counter-clockwise twist on the long axis.3. Since the trabeculated portions of the ventricles are the oldest developmental components, our observations support the hypothesis that the abnormal ventriculo-arterial connections could be in relation with a pathological myocardial process during early cardio-genesis.We are promoting new studies to investigate our anatomical observations.
More Related Videos
17:13Exploring Deep Space - Uncovering the Anatomy of Periventricular Structures to Reveal the Lateral Ventricles of the Human Brain
Published on: October 22, 2017
15:263D Modeling of the Lateral Ventricles and Histological Characterization of Periventricular Tissue in Humans and Mouse
Published on: May 19, 2015
Related Concept Videos
01:18Anatomy of the Brain: Ventricles
01:27Development of the Heart
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart...
01:16Chambers of the Heart
Deoxygenated blood from the body is received in the right...
01:16Spinal Cord: Cross-sectional Anatomy
Gray Matter and its Components
Central to the gray matter is...
01:15Aortic Regurgitation I: Introduction
01:27Mitral Valve Prolapse I: Introduction