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Wound dressing based on nonwoven viscose fabrics.
A Abou-Okeil1, A M Sheta2, A Amr1
1Textile Research Division, National Research Center, Dokki, Cairo, Egypt.
Carbohydrate Polymers
|April 23, 2014
Summary
This study developed advanced wound dressings from nonwoven viscose fabric treated with chitosan, polyvinyl alcohol (PVA), and silver nanoparticles (Ag NPs). These novel dressings demonstrated significant antibacterial properties and promoted complete wound healing in rabbit models within 21 days.
Area of Science:
- Materials Science
- Biomedical Engineering
- Textile Engineering
Background:
- Nonwoven fabrics are widely used in various applications, including medical textiles.
- Developing effective wound dressings with antibacterial properties is crucial for patient recovery.
- Chitosan and polyvinyl alcohol (PVA) are biocompatible polymers with potential for wound healing applications.
Purpose of the Study:
- To develop and evaluate novel wound dressings based on chitosan/PVA-treated nonwoven viscose fabric.
- To investigate the effect of chitosan and PVA concentrations on fabric properties like permeability and roughness.
- To assess the antibacterial efficacy and wound healing performance of chitosan/PVA/Ag nanoparticles treated fabric.
Main Methods:
- Nonwoven viscose fabric was treated with varying concentrations of chitosan and PVA using a pad-dry method.
- The treated fabrics were further immersed in a silver nanoparticle (Ag NPs) solution.
- Fabric properties (air/water permeability, roughness) and antibacterial activity were analyzed.
- The efficacy of the chitosan/PVA/Ag NPs treated fabric as a wound dressing was evaluated on rabbit models.
Main Results:
- Increasing PVA concentration enhanced air permeability, while water permeability showed an optimal concentration.
- Both chitosan and PVA treatments increased fabric roughness and improved antibacterial properties.
- The chitosan/PVA/Ag nanoparticles treated nonwoven viscose fabric demonstrated complete wound healing in rabbits within 21 days.
- Histopathological examination confirmed complete re-epithelialization and epidermis formation.
Conclusions:
- Chitosan/PVA/Ag nanoparticles treatment significantly enhances the properties of nonwoven viscose fabric for wound dressing applications.
- The developed wound dressing shows excellent antibacterial activity and promotes rapid, complete wound healing.
- This study highlights the potential of functionalized nonwoven fabrics as effective biomedical materials.
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