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Chronic wasting disease agents in nonhuman primates.
Emerging Infectious Diseases
|April 23, 2014
Summary
Chronic wasting disease (CWD) poses a risk to cervids. Research shows squirrel monkeys are highly susceptible to CWD, while cynomolgus macaques are not, indicating a potentially low zoonotic risk to humans.
Area of Science:
- Veterinary neurology
- Prion diseases
- Zoonotic disease research
Background:
- Chronic wasting disease (CWD) is a fatal prion disease affecting deer and related species.
- Understanding the zoonotic potential of CWD is crucial for public health.
- Primate models are essential for assessing disease transmission risks to humans.
Purpose of the Study:
- To evaluate the susceptibility of non-human primates to Chronic Wasting Disease.
- To determine if CWD can transmit to primate species via different inoculation routes.
- To assess the potential risk of CWD to human health.
Main Methods:
- Squirrel monkeys and cynomolgus macaques were inoculated with CWD.
- Inoculations were performed via intracerebral and oral routes.
- Primate susceptibility and disease progression were monitored.
Main Results:
- 100% of intracerebrally inoculated squirrel monkeys contracted CWD.
- 92% of orally inoculated squirrel monkeys showed susceptibility to CWD.
- Cynomolgus macaques did not develop CWD following inoculation.
Conclusions:
- Squirrel monkeys are highly susceptible to Chronic Wasting Disease.
- Cynomolgus macaques appear resistant to CWD infection.
- The study suggests a potentially low risk of human transmission from CWD.
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